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However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice. Salidroside improved the maturation, fertilization, and developmental competence of oocytes from reproductively old mice by maintaining the normal spindle\/chromosome structure and mitochondrial function. Oocyte transcriptomic and micro\u2010proteomic analysis revealed that salidroside restores oocyte quality by enhancing mitophagy in reproductively old mice. 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