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However, it is necessary to fully understand the mechanisms of long\u2010term effects and practical applications of these dietary interventions for health. A 10\u2010week intermittent fasting (IMF) regimen was implemented on the aging animals in the current study. The variations of cerebral functions were analyzed employing a comprehensive experimental design that includes behavioral tests, neuroimaging, and ultrastructural analysis, such as resting\u2010state functional MRI (rsfMRI), EEG\/EMG recordings, transmission electron microscopy, and immunohistochemistry. Over a 10\u2010week regimen, IMF significantly improved locomotor activity, motor coordination, and muscle strength compared to controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Resting\u2010state fMRI (rsfMRI) demonstrated that IMF modulates brain\u2010wide functional connectivity, enhancing communication between key brain regions. Advanced imaging techniques revealed increased expression of myelin\u2010related proteins, including myelin basic protein (MBP), and myelin\u2010associated glycoprotein (MAG), indicating enhanced myelin integrity and repair, particularly in axons with diameters &lt;\u2009400\u2009nm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). These findings suggest that IMF may mitigate age\u2010related declines by promoting better neuronal signaling. This study highlights the potential function of IMF as a non\u2010pharmacological intervention to promote brain health and mitigate cognitive decline in aging populations.\n                  <\/jats:p>","DOI":"10.1111\/acel.14476","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:40:36Z","timestamp":1736383236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhuang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences  Wuhan China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences  Wuhan China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, College of Light Industry and Food Engineering Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology First People Hospital of Foshan  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences  Wuhan China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunling","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Brain Diseases; 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