{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:01:26Z","timestamp":1784912486599,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Male fertility declines during aging. This process mainly affects spermatogonia and Sertoli cells, leading to impaired spermatogenesis and poor\u2010quality sperm production. Circular RNAs (circRNAs) are covalently closed RNA molecules produced by backsplicing. In the field of male reproduction, circRNAs boast great potential in the regulation of spermatogenesis and sperm morpho\u2010functional skills. However, their potential role in age\u2010related male reproductive anomalies remains largely elusive. Here, we analyzed the reproductive phenotype of the aged male mouse experimental model, pointing our attention to a putative functional link between circRNAs and Sertoli cell survival. Our results confirm several testicular age\u2010related defects including: (i) altered morphology of the seminiferous epithelium; (ii) affected spermatogenesis; and (iii) decreased sperm production. In particular, aged spermatozoa (SPZ) were decreased in number in association with low motility and abnormal morphology (sperm head anomalies and tail bents). The expression analysis of selective spermatic circRNAs demonstrated a de\u2010regulated expression profile in Aged versus Young SPZ. Among them, we turned the lens on circAbcb9 as a spermatic circRNA potentially involved in the Sertoli cell senescence pathway via the circRNA\/miRNA\/mRNA network (ceRNET). Indeed, a significant shutdown of circAbcb9\u2010dependent network associated with a prominent increase in Sertoli cell senescence occurred in Aged testis. Interestingly, circAbcb9 was also expressed in human SPZ at decreased levels in Aged men, suggesting a conserved role. Collectively, our study stimulates greater interest in circRNAs as involved in the molecular mechanisms behind the age\u2010related effect on Sertoli cell survival, also providing new implications for fused protein in sarcoma (FUS) protein in sertolian circRNA biogenesis.<\/jats:p>","DOI":"10.1111\/acel.70023","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T06:42:17Z","timestamp":1744958537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deciphering the Contribution of Circular\n                    <scp>RNAs<\/scp>\n                    to Age\u2010Related Decline in Sertoli Cell Survivor"],"prefix":"10.1111","volume":"24","author":[{"given":"Francesco","family":"Manfrevola","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mosca","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological, Pharmaceutical Sciences and Technologies University of Campania \u201cLuigi Vanvitelli\u201d  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza Grazia","family":"Mele","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Chioccarelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Martinez","sequence":"additional","affiliation":[{"name":"H\u00f4pital Couple\u2010Enfant, Centre Hospitalier Universitaire de Grenoble UM de G\u00e9n\u00e9tique Chromosomique  Grenoble France"},{"name":"Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences INSERM U1209, CNRS UMR5309  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Coutton","sequence":"additional","affiliation":[{"name":"H\u00f4pital Couple\u2010Enfant, Centre Hospitalier Universitaire de Grenoble UM de G\u00e9n\u00e9tique Chromosomique  Grenoble France"},{"name":"Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences INSERM U1209, CNRS UMR5309  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mattia","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaceleste","family":"Pezzullo","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological, Pharmaceutical Sciences and Technologies University of Campania \u201cLuigi Vanvitelli\u201d  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Fasano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Cobellis","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Potenza","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological, Pharmaceutical Sciences and Technologies University of Campania \u201cLuigi Vanvitelli\u201d  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-1794","authenticated-orcid":false,"given":"Rosanna","family":"Chianese","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Campania L. 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