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Chronic, low\u2010grade inflammation in peripheral tissues develops when lymphatic structure or function is impaired, as observed during aging. While aging has been associated with a broad range of heart pathophysiology, its effect on cardiac lymphatic vasculature has not been characterized. Here, we analyzed cardiac lymphatics in aged 20\u2010month\u2010old mice versus young 2\u2010month\u2010old mice. Aged hearts showed reduced lymphatic vascular density, more dilated vessels, and increased inflammation and fibrosis in peri\u2010lymphatic zones. As exercise has shown benefits in several different models of age\u2010related heart disease, we further investigated the effects of aerobic training on cardiac lymphatics. Eight weeks of voluntary wheel running attenuated age\u2010associated adverse remodeling of the cardiac lymphatics, including reversing their dilation, increasing lymph vessel density and branching, and reducing perilymphatic inflammation and fibrosis. Intravital lymphangiography demonstrated improved cardiac lymphatic flow after exercise training. Our findings illustrate that aging leads to cardiac lymphatic dysfunction, and that exercise can improve lymphatic health in aged animals.<\/jats:p>","DOI":"10.1111\/acel.70043","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T02:06:50Z","timestamp":1741918010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Exercise\u2010Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart"],"prefix":"10.1111","volume":"24","author":[{"given":"Kangsan","family":"Roh","sequence":"first","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-7835","authenticated-orcid":false,"given":"Haobo","family":"Li","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Anesthesia Critical Care, and Pain Medicine, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Nicole","family":"Freeman","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Anesthesia Critical Care, and Pain Medicine, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Scripps Research Institute, Department of Chemistry  California La Jolla USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Zazzeron","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care, and Pain Medicine, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care, and Pain Medicine, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siman","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care, and Pain Medicine, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xia","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Systems Biology, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Ralph Baldovino","family":"Guerra","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Stanley and Judith Frankel Institute for Heart and Brain Health, University of Michigan Medical Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Sheffield","sequence":"additional","affiliation":[{"name":"Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Padera","sequence":"additional","affiliation":[{"name":"Edwin L. 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