{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:51:31Z","timestamp":1790272291912,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000147","name":"Canadian Cancer Society","doi-asserted-by":"publisher","award":["706320"],"award-info":[{"award-number":["706320"]}],"id":[{"id":"10.13039\/501100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The female reproductive organs present with the earliest aging characteristics, such as a decline in fertility and estrous cyclicity. While age\u2010related changes in the ovary are well documented, it is unclear if any age\u2010associated changes occur in the other female reproductive organs, such as the oviduct\/Fallopian tube. At the distal end of aged oviducts in mice, we found vacuolated multi\u2010ciliated cells (MCCs) with a severely apically displaced and deformed nucleus. This phenotype was unique to the distal oviduct epithelium\u2014the infundibulum (INF) and ampulla (AMP). Ovariectomy did not affect the timeline of MCC vacuolation, suggesting little involvement of ovulation and hormonal regulation. MCC vacuolation was induced in hypoxia or hydroxyurea treatments in in\u00a0vitro organotypic culture of all oviduct regions, not limited to the INF\/AMP epithelium. This suggests a high oxygen demand in MCCs, compared to other cell types, and a uniquely stressed INF\/AMP epithelial microenvironment in\u00a0vivo. We found that the blood circulation of INF\/AMP depended on the ovarian artery, different from the rest of the oviduct epithelium, and its circulation declined along with ovarian activities. We conclude that a decline in local blood circulation and distinct cellular identity of the INF\/AMP epithelium caused age\u2010associated MCC vacuolation, reflecting its mild, chronically stressed microenvironment.<\/jats:p>","DOI":"10.1111\/acel.70051","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T12:39:13Z","timestamp":1746103153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aging\u2010Associated Vacuolation of Multi\u2010Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-4294","authenticated-orcid":false,"given":"Keerthana","family":"Harwalkar","sequence":"first","affiliation":[{"name":"Department of Human Genetics McGill University  Montreal Quebec Canada"},{"name":"Rosalind and Morris Goodman Cancer Institute (GCI) McGill 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