{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:53:53Z","timestamp":1793051633423,"version":"4.5.0"},"reference-count":149,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK007563"],"award-info":[{"award-number":["DK007563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R25HL106365\u201012"],"award-info":[{"award-number":["5R25HL106365\u201012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21DK119879"],"award-info":[{"award-number":["R21DK119879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD090061"],"award-info":[{"award-number":["HD090061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21TW012635"],"award-info":[{"award-number":["R21TW012635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK\u2010133698"],"award-info":[{"award-number":["R01DK\u2010133698"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MD007586"],"award-info":[{"award-number":["MD007586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA163069"],"award-info":[{"award-number":["CA163069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR025497"],"award-info":[{"award-number":["S10RR025497"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020526","name":"Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["DK020593"],"award-info":[{"award-number":["DK020593"]}],"id":[{"id":"10.13039\/100020526","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021144","name":"United Negro College Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021144","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["2022\u2010253529"],"award-info":[{"award-number":["2022\u2010253529"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1022355"],"award-info":[{"award-number":["1022355"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1021868.01"],"award-info":[{"award-number":["1021868.01"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2011577"],"award-info":[{"award-number":["2011577"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EES2112556"],"award-info":[{"award-number":["EES2112556"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EES1817282"],"award-info":[{"award-number":["EES1817282"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB1955975"],"award-info":[{"award-number":["MCB1955975"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000923","name":"Silicon Valley Community Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SDG27080009"],"award-info":[{"award-number":["16SDG27080009"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24IVPHA1297559"],"award-info":[{"award-number":["24IVPHA1297559"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445\u201006"],"award-info":[{"award-number":["UL1 TR000445\u201006"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["ANRF\/IRG\/2024\/001777\/LS"],"award-info":[{"award-number":["ANRF\/IRG\/2024\/001777\/LS"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["ANRF\/ECRG\/2024\/001042\/LS"],"award-info":[{"award-number":["ANRF\/ECRG\/2024\/001042\/LS"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Age\u2010related skeletal muscle atrophy, known as sarcopenia, is characterized by loss of muscle mass, strength, endurance, and oxidative capacity. Although exercise has been shown to mitigate sarcopenia, the underlying governing mechanisms are poorly understood. Mitochondrial dysfunction is implicated in aging and sarcopenia; however, few studies explore how mitochondrial structure contributes to this dysfunction. In this study, we sought to understand how aging impacts mitochondrial three\u2010dimensional (3D) structure and its regulators in skeletal muscle. We hypothesized that aging leads to remodeling of mitochondrial 3D architecture permissive to dysfunction and is ameliorated by exercise. Using serial block\u2010face scanning electron microscopy (SBF\u2010SEM) and Amira software, mitochondrial 3D reconstructions from patient biopsies were generated and analyzed. Across five human cohorts, we correlate differences in magnetic resonance imaging, mitochondria 3D structure, exercise parameters, and plasma immune markers between young (under 50\u2009years) and old (over 50\u2009years) individuals. We found that mitochondria are less spherical and more complex, indicating age\u2010related declines in contact site capacity. Additionally, aged samples showed a larger volume phenotype in both female and male humans, indicating potential mitochondrial swelling. Concomitantly, muscle area, exercise capacity, and mitochondrial dynamic proteins showed age\u2010related losses. Exercise stimulation restored mitofusin 2 (MFN2), one such of these mitochondrial dynamic proteins, which we show is required for the integrity of mitochondrial structure. Furthermore, we show that this pathway is evolutionarily conserved, as Marf, the MFN2 ortholog in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , knockdown alters mitochondrial morphology and leads to the downregulation of genes regulating mitochondrial processes. Our results define age\u2010related structural changes in mitochondria and further suggest that exercise may mitigate age\u2010related structural decline through modulation of mitofusin 2.\n                  <\/jats:p>","DOI":"10.1111\/acel.70054","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T01:41:34Z","timestamp":1745631694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["3\n                    <scp>D<\/scp>\n                    Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into\n                    <scp>MFN<\/scp>\n                    \u20102\u2010Mediated Changes"],"prefix":"10.1111","volume":"24","author":[{"given":"Estev\u00e3o","family":"Scudese","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"},{"name":"Laboratory of Biosciences of Human Motricity (LABIMH) of the Federal University of State of Rio de Janeiro (UNIRIO)  Rio de Janeiro Brazil"},{"name":"Sport Sciences and Exercise Laboratory (LaCEE) Catholic University of Petr\u00f3polis (UCP)  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zer","family":"Vue","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-4039","authenticated-orcid":false,"given":"Vernat","family":"Exil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Div. of Cardiology St. Louis University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Vang","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Garza","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Neikirk","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryanna","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane D.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmati","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Joan &amp; Sanford I. Weill Medical College of Cornell University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Rodman","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinuthia","family":"Kabugi","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010qiang","family":"Shao","sequence":"additional","affiliation":[{"name":"Central Microscopy Research Facility  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mungai","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma T.","family":"AshShareef","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innes","family":"Hicsasmaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Manus","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine N.","family":"Wanjalla","sequence":"additional","affiliation":[{"name":"Division of Infection Diseases, Department of Medicine Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Whiteside","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"},{"name":"Department of Neuroscience, Cell Biology and Physiology Wright State University  Dayton OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathi","family":"Dasari","sequence":"additional","affiliation":[{"name":"Department of Biology Indian Institute of Science Education and Research (IISER)  Tirupati AP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clintoria R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cell Biology and Physiology Wright State University  Dayton OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Damo","sequence":"additional","affiliation":[{"name":"Department of Life and Physical Sciences Fisk University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Gaddy","sequence":"additional","affiliation":[{"name":"Division of Infection Diseases, Department of Medicine Vanderbilt University Medical Center  Nashville TN USA"},{"name":"Tennessee Valley Healthcare Systems U.S. Department of Veterans Affairs  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Glancy","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda MD USA"},{"name":"NIAMS NIH  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Est\u00e9lio Henrique Martin","family":"Dantas","sequence":"additional","affiliation":[{"name":"Laboratory of Biosciences of Human Motricity (LABIMH) of the Federal University of State of Rio de Janeiro (UNIRIO)  Rio de Janeiro Brazil"},{"name":"Doctor's Degree Program in Nursing and Biosciences \u2013 PpgEnfBio Federal University of the State of Rio de Janeiro \u2013 UNIRIO  Rio de Janeiro RJ Brazil"},{"name":"Laboratory of Human Motricity Biosciences \u2013 LABIMH Federal University of the State of Rio de Janeiro \u2013 UNIRIO  RJ Brazil"},{"name":"Brazilian Paralympic Academy \u2013 APB  Brazil"},{"name":"Doctor's Degree Program in Health and Environment \u2013 PSA Tiradentes University \u2010 UNIT  Aracaju SE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kinder","sequence":"additional","affiliation":[{"name":"Artur S\u00e1 Earp Neto University Center \u2010 UNIFASE\u2010FMP Petr\u00f3polis Medical School  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlesha","family":"Kadam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanendra","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine Wake Forest University School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Scartoni","sequence":"additional","affiliation":[{"name":"Laboratory of Biosciences of Human Motricity (LABIMH) of the Federal University of State of Rio de Janeiro (UNIRIO)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"Baffi","sequence":"additional","affiliation":[{"name":"Sport Sciences and Exercise Laboratory (LaCEE) Catholic University of Petr\u00f3polis (UCP)  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie R.","family":"McReynolds","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences Pennsylvania State University, State College  PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology Oregon State University  Corvallis OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonya","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Medicine University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Border Biomedical Research Center The University of Texas at El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Wandira","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Busoga University  Iganga Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okwute M.","family":"Ochayi","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Baze University  Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalene","family":"Ameka","sequence":"additional","affiliation":[{"name":"KAVI Institute of Clinical Research University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepiso K.","family":"Masenga","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"},{"name":"Department of Physiological Sciences, School of Medicine and Health Sciences Mulungushi University  Livingstone Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanel","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College  Nashville US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"},{"name":"Department of Biomedical Sciences Meharry Medical College  Nashville US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College  Nashville US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Gaye","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics and Epidemiology Meharry Medical College  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Korolkova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology Meharry Medical College  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology Meharry Medical College  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret C.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Department of Pathology Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Katti","sequence":"additional","affiliation":[{"name":"Department of Biology Indian Institute of Science Education and Research (IISER)  Tirupati AP India"},{"name":"National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-952X","authenticated-orcid":false,"given":"Antentor","family":"Hinton","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12153"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13216"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0367com"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.09.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.02.069"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00719.2018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10010031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868073"},{"key":"e_1_2_8_11_1","first-page":"83","article-title":"Age\u2010Related Changes in the Skeletal Muscle Cells","volume":"21","author":"Beregi E.","year":"1988","journal-title":"Zeitschrift f\u00fcr Gerontologie"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0049"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0481"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64125"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00187"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00199"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01362.2013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204750120"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.092031"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.14119"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-110410-132529"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503062200"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211046"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.681237"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0033-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01883"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.01.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046293"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3791\/62045"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300186"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp179"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12289"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101358"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16138"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.236745"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu004"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000909"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617288114"},{"key":"e_1_2_8_41_1","first-page":"225","article-title":"Interleukin\u20106 and Aging: Blood Levels and Mononuclear Cell Production Increase With Advancing Age and In\u00a0Vitro Production Is Modifiable by Dietary Restriction","volume":"12","author":"Ershler W. B.","year":"1993","journal-title":"Lymphokine and Cytokine Research"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10944"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111802"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504880112"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-014-0281-4"},{"key":"e_1_2_8_46_1","first-page":"41","article-title":"Interleukin\u20106 in Acute Exercise and Training: What Is the Biological Relevance","volume":"12","author":"Fischer C. P.","year":"2006","journal-title":"Exercise Immunology Review"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01609-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101654"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7919"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12780"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010065"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0800"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.541040"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100414"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(02)00196-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24956-2"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.253443"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311310110"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102301"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00211"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200202"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31204"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-23-0382"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900365RR"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.01.011"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.1999.10608028"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.115877"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34445-9"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112486"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.165472"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2017.21.6.633"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2013.20.1.1"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.029"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00337.2011"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092177"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2454-z"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12863"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4235"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz401"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.13"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes577"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002464R"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-013-9571-6"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2012-0226"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0778-z"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2023.02.005"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2023.05.003"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300139"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0570-x"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00196.2019"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.07.020"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.168"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470942390.mo140169"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology5040038"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606786113"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2023.151365"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200221"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.359174"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.01.005"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00185.2012"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0340"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.186247"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111853"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66519"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696179"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.04.011"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00819.2013"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6139"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000605"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.206"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.153031"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac164"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab178"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310591"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271212"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20476"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.734509"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.0957"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106653"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108220109"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593084"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.070490"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948395"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.01.016"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101344"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29945-7"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041774"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.015"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes8120398"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199810000-00005"},{"key":"e_1_2_8_132_1","doi-asserted-by":"crossref","unstructured":"Stephens D. C. M.Mungai A.Crabtree et\u00a0al.2023.\u201cComponents of Isolated Skeletal Muscle Differentiated Through Antibody Validation.\u201dbioRxiv.https:\/\/doi.org\/10.1101\/2023.05.20.541600.","DOI":"10.1101\/2023.05.20.541600"},{"key":"e_1_2_8_133_1","first-page":"130","article-title":"Sarcopenia: Exercise as a Treatment Strategy","volume":"35","author":"Taaffe D. R.","year":"2020","journal-title":"Australian Family Physician"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-015-9860-3"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.021"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00281.2004"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.010"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14009"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00202.2023"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13322"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/807874"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606116200"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00348.2009"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.642717"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq2424"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248410385683"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70151-4"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.858286"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13005"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1939"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:23:45Z","timestamp":1770668625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":149,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/acel.70054"],"URL":"https:\/\/doi.org\/10.1111\/acel.70054","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.13.566502","asserted-by":"object"}]},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2023-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70054"}}