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The immunological profiles of volunteers residing in endemic and non\u2010endemic areas for chronic infectious diseases were analyzed at the early stage of SARS\u2010CoV\u20102 infection. A unique signature of inflammatory plasma mediators was identified in COVID\u201019 volunteers when compared to individuals with other flu\u2010like syndromes. COVID\u201019 severity correlated with high levels of inflammatory mediators; among them, CXCL9, a serum marker of aging. Patients who progressed to hospitalization displayed high frequencies of CD8\n                    <jats:sup>+<\/jats:sup>\n                    and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing exhaustion and senescence markers and showed reduced and more mature B cell repertoires, which are typical of senescence. They also had an acceleration of epigenetic age measured by DNA methylation. Therefore, severe COVID\u201019 correlated with phenotypic, functional, and epigenetic features of accelerated immunosenescence at the onset of infection.\n                  <\/jats:p>","DOI":"10.1111\/acel.70077","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:02:03Z","timestamp":1747652523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunosenescence Profile Is Associated With Increased Susceptibility to Severe\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1111","volume":"24","author":[{"given":"Lucas Haniel A.","family":"Ventura","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte 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