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This study demonstrated that dietary Se deficiency accelerated many age\u2010related gut microbial changes in aged telomere\u2010humanized C57BL\/6J diabetic mice in a sexually dimorphic manner, with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    showing the greatest enrichment in males. However, dietary Se deficiency did not enrich\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    in mature or middle\u2010aged male C57BL\/6J wild\u2010type mice. Oral gavage of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    alleviated Se deficiency\u2010induced type 2 diabetes\u2010like symptoms, reversed mucosal barrier dysfunction and gut inflammation, and resulted in a trend of symbiotic and competitive suppression changes in certain gut bacteria in mature wild\u2010type mice under conventional conditions. The beneficial effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    appeared to be independent of selenoproteins sensitive to dietary Se deficiency, such as GPX1, SELENOH, and SELENOW, in the liver and muscle. Altogether, these results show that dietary Se deficiency accelerates age\u2010related\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    enrichment specifically in aged male mice with severe insulin resistance and pancreatic senescence, indicating a potential hormetic response to Se deficiency through reshaped gut microbiota, which alleviates hyperglycemia and partially compensates for healthspan decline.\n                  <\/jats:p>","DOI":"10.1111\/acel.70130","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T12:30:27Z","timestamp":1750422627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dietary Selenium Deficiency Accelerates the Onset of Aging\u2010Related Gut Microbial Changes in Aged Telomere\u2010Humanized Mice, With\n    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