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Although the effects of progerin on multiple tissues have been previously studied, its impact on brain development is not completely understood. We established cortical organoids derived from HGPS patient\u2010induced pluripotent stem cells (iPSCs) from patients with HGPS to investigate the role of progerin in the brain. HGPS cortical organoids showed hallmarks of HGPS pathology, including elevated progerin expression and irregular nuclear morphology during early developmental stages. Additionally, we observed abnormal morphology and increased cellular senescence specifically in the rosette regions of HGPS organoids. This senescence appeared to interfere with normal neuronal differentiation, resulting in a significant reduction in mature neuron development and synapse formation in HGPS cortical organoids. Transcriptome profiling of HGPS cortical organoids revealed the downregulation of key genes related to neural development and synapse formation, with these changes persisting over time, potentially contributing to impaired neuronal differentiation and maturation. These findings suggest the role of progerin in early neural development and establish cortical organoids as a model for studying HGPS\u2010related brain development.<\/jats:p>","DOI":"10.1111\/acel.70143","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T13:05:59Z","timestamp":1752411959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient\u2010Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson\u2010Gilford Progeria Syndrome"],"prefix":"10.1111","volume":"24","author":[{"given":"Seeun","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul\u2010Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Graduate 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