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Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH ratio. Thus, in the current study, we systematically investigate the effects of a CD38\u2010targeting peptide vaccine (CD38\u2010vaccine) on aging\u2010associated phenotypes in mice. The CD38\u2010vaccine induces a robust T\u2010cell immune response, selectively depletes CD38\n                    <jats:sup>+<\/jats:sup>\n                    myeloid cells in the spleen, and ameliorates age\u2010related physical and cognitive function decline. Metabolically, vaccination improves glucose tolerance, enhances oxygen consumption, and decreases the number of senescent cells and mRNA levels of senescence\u2010related genes in liver tissues. Vaccination also increases the NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH ratio in the liver tissues, enhances oxidative metabolism, and reduces glycolysis. These findings indicate that targeting CD38 via vaccination is a promising strategy for ameliorating aging\u2010associated phenotypes.\n                  <\/jats:p>","DOI":"10.1111\/acel.70147","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:45:22Z","timestamp":1750826722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>CD38<\/scp>\n                    \u2010Targeting Peptide Vaccine Ameliorates Aging\u2010Associated Phenotypes in Mice"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-4744","authenticated-orcid":false,"given":"Shangcheng","family":"Yu","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases Tsinghua University  Beijing 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Severe, and Rare Diseases Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangze","family":"Feng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking Union Medical College Hospital  Beijing 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