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We have previously shown that perinatal dietary supplementation with the nutrient choline ameliorates cognitive deficits and reduces amyloidosis across the brain in\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    AD model mice. Here, we analyzed transcriptomic abnormalities in these mice and tested the hypothesis that they may be attenuated by perinatal choline supplementation (PCS). Wild\u2010type (WT) and\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    dams consumed a diet containing 1.1 (control) or 5\u2009g\/kg (supplemented) of choline chloride from 2\u2009weeks prior to mating until weaning. At 3, 6, 9, or 12\u2009months of age, the offspring RNA was sequenced in the hippocampus and cerebral cortex. As compared to WT, the\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    mice reared on the control diet had age\u2010dependent upregulation of expression of mRNAs and lncRNAs related to inflammation and reduced expression of mRNAs related to neuronal function. As compared to\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    mice on the control diet, PCS\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    mice increased expression of synaptic genes and downregulated inflammation\u2010related genes starting at 6\u2009months in the cortex; increased expression of GABAergic function and ATP metabolism genes, and decreased expression of inflammatory genes in the hippocampus at 12\u2009months. These changes counteracted the effects of\n                    <jats:italic>App<\/jats:italic>\n                    <jats:sup>NL\u2010G\u2010F<\/jats:sup>\n                    genotype seen in mice on the control diet. The expression of many of these choline\u2010protected genes correlated with clinical dementia rating, inflammation, and tauopathy in human postmortem dorsolateral prefrontal cortex AD samples, indicating their relevance to the disease process. The results suggest that adequate choline intake could be a preventive strategy for AD.\n                  <\/jats:p>","DOI":"10.1111\/acel.70148","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:57:22Z","timestamp":1760407042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease\u2010Like Brain Transcriptomic Signatures in\n                    <scp>\n                      <i>App<\/i>\n                      <sup>NL\u2010G\u2010F<\/sup>\n                    <\/scp>\n                    Mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Thomas A.","family":"Bellio","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Krunic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Pharmacology, Physiology, and Biophysics Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Campion","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Dupaguntla","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Labadorf","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Bioinformatics Program Boston University  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Veterans Affairs Medical Center  Bedford Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-3942","authenticated-orcid":false,"given":"Honghuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany J.","family":"Mellott","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-3122","authenticated-orcid":false,"given":"Jan K.","family":"Blusztajn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"2025 Alzheimer's Disease Facts and Figures.2025.\u201c2025 Alzheimer's Disease Facts and 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S.Wright J. M.Bonner et\u00a0al.2024.\u201cSingle\u2010Cell Atlas of ABCA7 Loss\u2010of\u2010Function Reveals Impaired Neuronal Respiration via Choline\u2010Dependent Lipid Imbalances.\u201d bioRxiv 2023.09.05.556135.https:\/\/doi.org\/10.1101\/2023.09.05.556135.","DOI":"10.1101\/2023.09.05.556135"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/NT.0000000000000302"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.060"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00660"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac193"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.2009.00246.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.236"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T21:59:45Z","timestamp":1771279185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":69,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/acel.70148"],"URL":"https:\/\/doi.org\/10.1111\/acel.70148","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70148"}}