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The smoke from burning cigarettes is a key environmental risk factor that leads to accelerated aging and the occurrence of numerous diseases. Meanwhile, cigarette smoke and aging are both prominent risk factors for age\u2010related macular degeneration (AMD). This study demonstrates that long\u2010term exposure to cigarette smoke can impair retinal function and induce the aging of retinal pigment epithelium (RPE). Meanwhile, the plasma of rats after long\u2010term exposure to cigarette smoke can trigger DNA damage and cellular senescence in\u00a0vitro. In addition, naphthalene and its metabolites (1,2\u2010dihydroxynaphthalene and 1,2\u2010naphthoquinone) derived from cigarette smoke have been identified as an important factor contributing to RPE damage caused by cigarette exposure. Finally, we found that the aging of RPE induced by smoking can be alleviated through smoking cessation, probably because quitting smoking reduces the accumulation of these toxic chemicals in plasma and within the eyes.<\/jats:p>","DOI":"10.1111\/acel.70150","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T22:27:09Z","timestamp":1750458429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Naphthalene Metabolites From Long\u2010Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment Epithelium"],"prefix":"10.1111","volume":"24","author":[{"given":"Tingting","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji Hospital, School of Medicine Tongji University  Shanghai 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