{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:02:33Z","timestamp":1790395353474,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 108\u20102320\u2010B\u2010010\u2010043\u2010MY3"],"award-info":[{"award-number":["MOST 108\u20102320\u2010B\u2010010\u2010043\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111\u20102320\u2010B\u2010A49\u2010010\u2010MY3"],"award-info":[{"award-number":["MOST 111\u20102320\u2010B\u2010A49\u2010010\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI\u2010113\u201020"],"award-info":[{"award-number":["CI\u2010113\u201020"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    COVID\u201019 mortality disproportionately affects the elderly, yet the cellular and molecular factors contributing to age\u2010related immune system remodeling remain unclear. Using SARS\u2010CoV\u2010derived ssRNA sequences, we modeled age\u2010dependent immune responses in mice. Aged mice exhibited higher mortality and severe lung inflammation upon viral ssRNA challenge, mirroring clinical observations. We uncovered a pre\u2010existing inflammatory state in aged mice, characterized by elevated baseline levels of specific immune cells and cytokines correlating with poor outcomes. Age\u2010related immune dysfunction stemmed from impaired IRF7 signaling and defective SNARE\u2010mediated cytokine secretion in CD11b\n                    <jats:sup>+<\/jats:sup>\n                    cells. Notably, the adoptive transfer of young CD11b\n                    <jats:sup>+<\/jats:sup>\n                    cells to aged mice exposed to SARS\u2010CoV2 ssRNA reduced mortality, alleviated lung inflammation, and normalized cytokine profiles. These findings provide insights into age\u2010related immune dysregulation during viral challenges and suggest potential therapeutic strategies for severe COVID\u201019 in the elderly.\n                  <\/jats:p>","DOI":"10.1111\/acel.70154","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T13:05:59Z","timestamp":1752411959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired Cytokine Secretion Contributes to Age\u2010Dependent Immune Dysfunction in\n                    <scp>SARS<\/scp>\n                    Coronavirus Response and Is Restored by Young\n                    <scp>CD11b<\/scp>\n                    \u2010Positive Cell Transfer"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-0102","authenticated-orcid":false,"given":"Yu\u2010Xuan","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Physiology, College of Medicine National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-8644","authenticated-orcid":false,"given":"Chih\u2010Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Experimental Animal Center, Institute of Preventive Medicine National Defense Medical College  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4337-2766","authenticated-orcid":false,"given":"Jui\u2010Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Laboratory Science in Medicine, College of Biomedical Science and Engineering National Yang Ming Chiao Tung University  Taipei City 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Chang\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Physiology, College of Medicine National Yang Ming Chiao Tung University  Taipei City Taiwan"},{"name":"Department of Orthopedics and Rehabilitation University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5779-0347","authenticated-orcid":false,"given":"Min\u2010Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Physiology, College of Medicine National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5646-6135","authenticated-orcid":false,"given":"Chuen\u2010Mi","family":"Yang","sequence":"additional","affiliation":[{"name":"Experimental Animal Center, Institute of Preventive Medicine National Defense Medical College  New Taipei City 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