{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:53Z","timestamp":1787013773752,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG060395"],"award-info":[{"award-number":["R01 AG060395"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG048366"],"award-info":[{"award-number":["R01 AG048366"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007576"],"award-info":[{"award-number":["T32 HL007576"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL139451"],"award-info":[{"award-number":["T32 HL139451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004492"],"award-info":[{"award-number":["I01 BX004492"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cellular senescence is a state of persistent cell cycle arrest and is a critical contributor to arterial aging. The primary drivers of cellular senescence are the DNA damage response (DDR) and telomere dysfunction, which is induced by increasing exposure to DNA\u2010damaging stimuli such as atheroprone shear stress. While late\u2010life aerobic exercise is an effective intervention to mitigate arterial aging, its specific impact on the DDR and telomere dysfunction is unknown and may not show uniform benefits across aortic regions subjected to atheroprone and non\u2010atheroprone shear stress. This study investigates the influence of late\u2010life aerobic exercise on DDR and telomere dysfunction in endothelial cells (EC) and vascular smooth muscle cells (VSMC) within the aortic regions exposed to distinct shear stress patterns. Old male C57BL6 mice were randomly assigned to a negative control (NC) group and habitual voluntary wheel running (VWR) groups for 16\u2009weeks. The habitual VWR groups were further categorized into low (LR), moderate (MR), and high running (HR) groups based on their daily running distance throughout the intervention. EC and VSMC DDR and telomere dysfunction in NC, LR, and MR groups were comparable across the aortic regions. Interestingly, EC DDR and telomere dysfunction were mitigated in the non\u2010atheroprone aortic regions in HR, but not in VSMC. These improvements were independent of telomere length. Collectively, these data provide evidence that late\u2010life aerobic exercise selectively mitigates DDR and telomere dysfunction in ECs within non\u2010atheroprone aortic regions, rather than atheroprone aortic regions, in an exercise volume\u2010dependent manner, independent of telomere length.<\/jats:p>","DOI":"10.1111\/acel.70196","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T04:50:02Z","timestamp":1756356602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Late\u2010Life Aerobic Exercise Attenuates\n                    <scp>DNA<\/scp>\n                    Damage and Telomere Dysfunction in Non\u2010Atheroprone but Not in Atheroprone Aortic Regions"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-5673","authenticated-orcid":false,"given":"Jisok","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-5516","authenticated-orcid":false,"given":"Hossein","family":"Abdeahad","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Lesniewski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City Utah USA"},{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City Utah USA"},{"name":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center  Salt Lake City Utah USA"},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah  Salt Lake City Utah USA"},{"name":"Department of Nutrition and Integrative Physiology University of Utah  Salt Lake City Utah USA"},{"name":"Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center  Salt Lake City Utah USA"},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah  Salt Lake City Utah USA"},{"name":"Department of Biochemistry University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.86.2.185"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010022\u201000739\u20100"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010022\u201000681\u20106"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114146"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170633"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010020\u201000212\u20101"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1708"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010020\u201000177\u20101"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000048892.83521.58"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2009.12.009"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00510.2009"},{"key":"e_1_2_5_14_1","unstructured":"National Center for Health.2017.\u201cHealth United States 2016: With Chartbook on Long\u2010Term Trends in Health.\u201d Hyattsville (MD): National Center for Health Statistics (US)."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003307\u20107"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90553.2008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010011\u20100313\u20106"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.114.303415"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00393.2023"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05\u20101607"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.113.280883"}],"container-title":["Aging 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