{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:57:45Z","timestamp":1792054665365,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Advancing age is accompanied by an accumulation of senescent T cells that secrete pro\u2010inflammatory senescence\u2010associated secretory phenotype (SASP) molecules. Gut\u2010microbiota\u2010derived signals are increasingly recognised as immunomodulators. In the current study, we demonstrated that ageing and the accumulation of senescent T cells are accompanied by a reduction in microbial\u2010derived short\u2010chain fatty acids (SCFAs). Culturing aged T cells in the presence of butyrate suppresses the induction of a senescence phenotype and inhibits the secretion of pro\u2010inflammatory SASP factors, such as IL6 and IL8. Administration of faecal supernatants from young mice rich in butyrate prevented in\u00a0vivo accumulation of senescent spleen cells in aged mice. The molecular pathways governing butyrate's senomorphic potential include a reduced expression of DNA damage markers, lower mitochondrial ROS accumulation, and downregulation of mTOR activation, which negatively regulates the transcription factor NF\u03baB. Our findings establish butyrate as a potent senomorphic agent and provide the evidence base for future microbiome restitution intervention trials using butyrate supplements for combating T cell senescence, ultimately reducing inflammation and combating age\u2010related pathologies to extend lifelong health.<\/jats:p>","DOI":"10.1111\/acel.70257","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:43:29Z","timestamp":1762523009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Defining Microbiota\u2010Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age\u2010Related T Cell Senescence"],"prefix":"10.1111","volume":"24","author":[{"given":"Nia Paddison","family":"Rees","sequence":"first","affiliation":[{"name":"Department of Inflammation and Aging, School of Infection, Inflammation and Immunology University of Birmingham  Birmingham 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