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Impaired brain drainage and excessive accumulation of metabolites and toxins such as advanced glycation end products (AGEs) are characteristics of aging that contribute to the development of neurological disorders. Recent discoveries have highlighted the role of meningeal lymphatic vessels (MLVs) in the clearance of toxic metabolites, cells, tumors, and viruses from the brain, positioning them as significant targets for the treatment of various brain diseases. In this study, we demonstrate that noninvasive 1275\u2010nm photobiomodulation (PBM) effectively improves brain drainage and promotes lymphatic clearance of AGEs in a D\u2010galactose\u2010induced aging model (AM) in male mice, while being safe due to its minimal thermal effects. These improvements are associated with nitric oxide release\u2010mediated dilation of MLVs. PBM can also effectively ameliorate redox imbalance, neuroinflammation, and neuronal damage, as well as improve spatial learning ability and short\u2010term recognition memory in AM mice. These findings introduce a promising and easily accessible strategy for nonpharmacological phototherapy of meningeal brain drainage and neurological decline in individuals with aging and aging\u2010related neurodegenerative diseases, offering high potential for rapid implementation into routine clinical practice.<\/jats:p>","DOI":"10.1111\/acel.70261","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:41:39Z","timestamp":1760557299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["1275\u2010nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging\u2010Related Neurological Decline"],"prefix":"10.1111","volume":"24","author":[{"given":"Hao","family":"Lin","sequence":"first","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced Biomedical Imaging Facility Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced Biomedical Imaging Facility Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihang","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced Biomedical Imaging Facility Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced 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Optical Electronic Information Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-7137","authenticated-orcid":false,"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced Biomedical Imaging Facility Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics \u2010 Advanced Biomedical Imaging Facility Huazhong University of Science and Technology  Wuhan Hubei 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