{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:13:32Z","timestamp":1781781212937,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hutchinson\u2010Gilford Progeria Syndrome (HGPS) is a rare, fatal genetic disorder characterized by accelerated aging. The accumulation of an abnormal and toxic protein called progerin within HGPS nuclei disrupts cellular processes, including gene expression and DNA repair. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defense, is one of the hallmarks of HGPS. To identify novel molecular mechanisms underlying HGPS pathogenesis, we performed miRNA expression profiling in HGPS compared to healthy control fibroblasts. We identified 10 differentially expressed (DE) miRNAs between HGPS and control cells. We focused on miR\u2010140\u20105p and miR\u2010140\u20103p, 2 miRNAs upregulated in HGPS fibroblasts. miR\u2010140\u20105p is known to directly target the transcript of\n                    <jats:italic>NRF2<\/jats:italic>\n                    , a master regulator of the antioxidant response. Using in\u00a0vitro mimic and antimiR transfections, we demonstrated that miR\u2010140\u20105p overexpression in HGPS fibroblasts results in the downregulation of the NRF2\/KEAP1\/HO\u20101 antioxidant pathway, leading to increased oxidative stress. Furthermore, our results indicate that miR\u2010140\u20105p overexpression induces mitochondrial dysfunction, characterized by a reduced oxidative phosphorylation capacity and affects other hallmarks of aging. By targeting regulation of oxidative stress and mitochondrial function through NRF2, miR\u2010140\u20105p may play a pivotal role in the pathophysiology of HGPS and open new therapeutic avenues.\n                  <\/jats:p>","DOI":"10.1111\/acel.70276","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:04:46Z","timestamp":1761915886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>miR<\/scp>\n                    \u2010140\u20105p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson\u2010Gilford Progeria Syndrome Fibroblasts Through\n                    <scp>NRF2<\/scp>\n                    Pathway"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2148-9768","authenticated-orcid":false,"given":"L\u00e9a","family":"Toury","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, MMG  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-6951","authenticated-orcid":false,"given":"Diane","family":"Frankel","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, APHM, INSERM MMG, Service de Biologie Cellulaire, H\u00f4pital la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Nael","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, MMG  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-2024","authenticated-orcid":false,"given":"Mario","family":"Abaji","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, APHM, INSERM MMG, M2GM, H\u00f4pital la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Le Goff","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, MMG  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Basset","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, MMG  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-0135","authenticated-orcid":false,"given":"Coraline","family":"Airault","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, MMG  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-3872","authenticated-orcid":false,"given":"Bertrand","family":"Vernay","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS INP UMR7051, Neuro\u2010Cellular Imaging Service and Nikon Center for Neuro\u2010NanoImaging  Marseille 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1107803"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147474"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.239"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07078-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.03.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.06.163"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.09.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01629"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12766"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103757"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12190"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.06.007"},{"key":"e_1_2_10_15_1","volume-title":"GeneReviews","author":"Gordon 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