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Converging evidence indicates that hippocampal mRNA translation (protein synthesis) is defective in AD. Here, we show that genetic reduction of the translational repressors, Fragile X messenger ribonucleoprotein (FMRP) or eukaryotic initiation factor 4E (eIF4E)\u2010binding protein 2 (4E\u2010BP2), prevented the attenuation of hippocampal protein synthesis and memory impairment induced by AD\u2010linked amyloid\u2010\u03b2 oligomers (A\u03b2Os) in mice. Moreover, genetic reduction of 4E\u2010BP2 rescued memory deficits in aged APPswe\/PS1dE9 (APP\/PS1) transgenic mouse model of AD. Our findings demonstrate that strategies targeting repressors of mRNA translation correct hippocampal protein synthesis and memory deficits in AD models. Results suggest that modulating pathways controlling brain mRNA translation may confer memory benefits in AD.<\/jats:p>","DOI":"10.1111\/acel.70315","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:50:05Z","timestamp":1764766205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Reduction of the Translational Repressors\n                    <scp>FMRP<\/scp>\n                    and\n                    <scp>4E<\/scp>\n                    \u2010\n                    <scp>BP2<\/scp>\n                    Preserves Memory in Mouse Models of Alzheimer's Disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-3307","authenticated-orcid":false,"given":"Felipe C.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro  Rio de Janeiro 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University  Kingston Ontario Canada"},{"name":"D'or Institute for Research and Education  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mychael V.","family":"Lourenco","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Department of Biochemistry and Tissue Biology State University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-1138","authenticated-orcid":false,"given":"Argel","family":"Aguilar\u2010Valles","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Carleton University  Ottawa Ontario 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