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However, the age of onset, extent of transcriptomic changes and how they unfold are not fully understood. We performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, and testis) from male C57BL\/6J mice across much of the murine lifespan covering 3\u2010, 5\u2010, 8\u2010, 14\u2010, 20\u2010 and 26\u2010month\u2010old animals. Our analysis revealed that age\u2010related transcriptomic shifts vary in both timing and extent, with early shifts in lung, spleen, and testis; mid\u2010life changes in heart, kidney, and skeletal muscle; and later alterations in brain and liver. The extent of age\u2010related transcriptomic changes ranged from very low (testis) to high (kidney, liver, spleen). A linear mixed\u2010effects model identified genes with tissue\u2010specific aging trajectories. By integrating hub gene analysis and functional enrichment, we uncovered aging signatures that are either tissue\u2010specific or shared across multiple organs, including those related to immune response, mitochondrial dysfunction, extracellular matrix remodeling, and cellular senescence. 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