{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:13:54Z","timestamp":1782828834743,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This systematic review and meta\u2010analysis aims to identify the most frequently reported blood\u2010based biomarkers (BBMs) in randomised controlled trials (RCTs) addressing sarcopenia management, and to perform a preliminary evaluation of the effects of sarcopenia\u2010specific interventions on BBMs concentrations. Medline, Embase and CENTRAL databases were searched to retrieve RCTs published until March 2024 (PROSPERO: CRD42024603238) on older participants with sarcopenia. Eligible studies applied a consensus definition of sarcopenia and reported BBM values before and after intervention. Meta\u2010analyses were performed for BBMs reported in a minimum of 2 RCTs using a random effects model with a standardised mean difference (SMD) and a 95% confidence interval. Among 58 RCTs on sarcopenia management, only 21 (36.2%) assessed BBMs and none involved pharmacological interventions. Altogether, 47 distinct BBMs were identified. The most frequently reported were C\u2010reactive protein, interleukin 6, tumour necrosis factor \u03b1, Insulin\u2010like Growth Factor 1 (IGF\u20101). Muscle\u2010specific BBM, follistatin, growth differentiation factor 8 and 15 were assessed in only 2 RCTs. Among non\u2010muscle\u2010specific BBMs, IGF\u20101 was significantly impacted by the studied interventions (SMD\u2009=\u20090.46, CI\u2009=\u2009[0.04; 0.88]). However, this change was not significant when analyses were restricted to RCTs reporting significant improvement in key sarcopenia measures. Despite substantial heterogeneity, few BBMs assessed in sarcopenia RCTs were muscle\u2010specific and limited biomarkers responded to interventions. There is an urgent need to adopt recommendations regarding muscle\u2010specific BBMs to be assessed in sarcopenia RCTs. Developing a standardised Core Outcome Set for sarcopenia intervention studies would enhance the standardisation of sarcopenia RCTs and ultimately improve disease management.<\/jats:p>","DOI":"10.1111\/acel.70361","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:55:16Z","timestamp":1768204516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Frequently Reported Blood Biomarkers in Sarcopenia Clinical Trials: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2723-2840","authenticated-orcid":false,"given":"Emma","family":"Calluy","sequence":"first","affiliation":[{"name":"Public Health Aging Research &amp; Epidemiology (PHARE) Group, Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), Department of Biomedical Sciences\u2010Faculty of Medicine University of Namur  Namur Belgium"},{"name":"Department of Clinical Chemistry, Center for Interdisciplinary Research on Medicines Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yveline","family":"Malrechauff\u00e9","sequence":"additional","affiliation":[{"name":"Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), Faculty of Medicine, Department of Pharmacy University of Namur  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Boretti","sequence":"additional","affiliation":[{"name":"Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), Faculty of Medicine, Department of Pharmacy University of Namur  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Van Heden","sequence":"additional","affiliation":[{"name":"Public Health Aging Research &amp; Epidemiology (PHARE) Group, Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), Department of Biomedical Sciences\u2010Faculty of Medicine University of Namur  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5172","authenticated-orcid":false,"given":"Dolores","family":"Sanchez\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Geriatrics Department Brugmann University Hospital, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Rehabilitation Research Group Hospital Del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoke Mun","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Faculty of Medicine and Health Sciences University Putra Malaysia  Serdang Malaysia"},{"name":"Malaysian Research Institute on Ageing University Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Cavalier","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Center for Interdisciplinary Research on Medicines Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5316-3108","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Ladang","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Center for Interdisciplinary Research on Medicines Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Reginster","sequence":"additional","affiliation":[{"name":"Protein Research Chair, Biochemistry Department, College of Science King Saud University  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-5298","authenticated-orcid":false,"given":"Jonathan","family":"Douxfils","sequence":"additional","affiliation":[{"name":"Research Unit in Clinical Pharmacology and Toxicology (URPC), NAmur Research Institute for LIfe Sciences (NARILIS), Faculty of Medicine, Department of Pharmacy University of Namur  Namur Belgium"},{"name":"QUALIresearch, QUALIblood s.a.  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