{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:55:38Z","timestamp":1792047338475,"version":"4.4.0"},"reference-count":190,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Age\u2010related decline in physical function is a hallmark of aging and a major driver of morbidity, disability, and loss of independence in older adults, yet the molecular processes linking muscle aging to functional deterioration remain incompletely defined. Emerging evidence implicates ferroptosis, defined as iron\u2010dependent, lipid peroxidation\u2010driven cell death, as a compelling but underexplored contributor to age\u2010related muscle wasting and weakness. Although ferroptosis signatures appear in aged muscle across cellular, animal, and human studies, their causal role in functional decline has not been clearly established. Here, we synthesize current evidence to propose a framework in which iron dyshomeostasis, impaired antioxidant defenses, and dysregulated ferritinophagy converge to create a pro\u2010ferroptotic milieu that compromises muscle energetics, structural integrity, and regenerative capacity. We delineate key knowledge gaps, including the absence of ferroptosis\u2010specific biomarkers in human muscle and limited longitudinal data linking ferroptotic stress to mobility outcomes. Finally, we highlight potential therapeutic opportunities targeting iron handling and lipid peroxidation pathways. A better understanding of the contribution of ferroptosis to muscle aging may enable development of mechanistically informed biomarkers and interventions to preserve strength and mobility in older adults.<\/jats:p>","DOI":"10.1111\/acel.70367","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:18:31Z","timestamp":1768396711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0838-0122","authenticated-orcid":false,"given":"Rola S.","family":"Zeidan","sequence":"first","affiliation":[{"name":"Department of Physiology and Aging, College of Medicine University of Florida  Gainesville Florida USA"},{"name":"Department of Health Outcomes and Biomedical Informatics College of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Biomedical Informatics College of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Picca","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery LUM University  Casamassima Italy"},{"name":"Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Marzetti","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS  Rome Italy"},{"name":"Department of Geriatrics, Orthopedics and Rheumatology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"Leeuwenburgh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Collins","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department Institute of Food and Agricultural Sciences, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10703"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac139"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12685"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315039"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00071"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.12.015"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201003548\u20109"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.178316"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050965"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5010007"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7080102"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.568S"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.12.002"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44324\u2010024\u201000045\u2010y"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jp287938"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000902\u20105"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13678"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP287090"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00229.2021"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf4345"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050865"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.637162"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004369\u2010z"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005716\u20100"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.941093"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116047"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010025\u201002121\u20100"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001019\u20108"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314674.118"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0047\u20106374(98)00005\u20100"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102761"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.09.005"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.08.011"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14090672"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12700"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00458.2001"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12160"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.08.015"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.07.026"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4911205"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85289"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010024\u201004719\u20106"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114538"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.70124"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7619418"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13285"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010052016\u2010100247"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1557218"},{"issue":"2","key":"e_1_2_15_55_1","first-page":"345","article-title":"Enhanced Lipid Peroxidation in Synoviocytes From Patients With Osteoarthritis","volume":"30","author":"Grigolo B.","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121977"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001251\u20100"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14111369"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb06182.x"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00165"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13779"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001482\u20102"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.09.003"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010022\u201002242\u20105"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.02.007"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201086333\u2010z"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.1137"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010044"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12876"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15519"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.1.81"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2022.100483"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi300382"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.02.031"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955128"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071078"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2024.101414"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270659"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2238"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194968"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234945"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2023.107872"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010018\u20100179\u20103"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090105"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S90413"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2023.07.003"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020173"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6782"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956361"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12102954"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102298\u20102"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.83348"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11040755"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuae195"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.70109"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.02.005"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.933732"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010025\u201005592\u20101"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893057"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013472"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00060.2017"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u20100779"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.640"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1052540"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103847"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309021150"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005022\u20103"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21559"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181881"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109610(97)89593\u20101"},{"issue":"1","key":"e_1_2_15_114_1","first-page":"30","article-title":"Synovial Iron Deposition in Osteoarthritis and Rheumatoid Arthritis","volume":"7","author":"Ogilvie\u2010Harris D. J.","year":"1980","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01172"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020249"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1268047"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.267419"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.007"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201007312\u20102"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201070792\u20107"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121525"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122579"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.01.010"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk1200"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001969\u2010z"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010023\u201000247\u2010y"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1297.070"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.09.001"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00422"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio807"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000131\u2010w"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010024\u201000398\u20106"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/loae008"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.10.049"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2010"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.01.016"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.01.002"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2008.00418.x"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9999612"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21239"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010024\u201001581\u20106"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001606\u20101"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002487"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212463"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010020\u201000441\u20101"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1622544"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010018\u20103961\u20105"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010025\u201008890\u20108"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010011\u20109277\u20106"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201057379\u20103_19"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101185"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.027"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11040731"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.02.005"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.02.011"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2017.05.006"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010022\u201001183\u20102"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1378853"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010021\u201000910\u2010z"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863\u2010020\u20100836\u20107"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201016917\u20102"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1051866"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201060759\u2010z"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.11.002"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010013\u20100091\u20102"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201006\u2010027631"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001365\u20106"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000907\u20100"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010025\u201000912\u20105"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2011.10.011"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002865"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000324\u20108"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.53126"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u201000428\u20109"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnac003"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:106:2:123"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110108"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201092501\u2010y"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.08.124"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101510"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2024.100212"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112333"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i15.4382"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.030"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.02.564"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201006691\u2010w"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1415417"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:19:36Z","timestamp":1772972376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":190,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/acel.70367"],"URL":"https:\/\/doi.org\/10.1111\/acel.70367","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70367"}}