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Although anti\u2010VEGF therapies have demonstrated clinical effectiveness, significant challenges including drug resistance and the need for frequent intravitreal injections persist. As natural nanovesicles, exosomes derived from mesenchymal stem cell (MSC) can mediate intercellular communication, making them an attractive alternative for modulating cellular processes. This study explored the anti\u2010angiogenic effects of MSC\u2010derived exosomes in nAMD, with particular emphasis on the role of a specific exosomal lncRNA\n                    <jats:italic>lnc\u2010AGT\u20103<\/jats:italic>\n                    . Our results showed that\n                    <jats:italic>lnc\u2010AGT\u20103<\/jats:italic>\n                    expression was reduced in both nAMD patients and choroidal neovascularization (CNV) models, and its overexpression effectively inhibited pathological angiogenesis in\u00a0vitro\n                    <jats:italic>and<\/jats:italic>\n                    in\u00a0vivo\n                    <jats:italic>.<\/jats:italic>\n                    Mechanistically,\n                    <jats:italic>lnc\u2010AGT\u20103<\/jats:italic>\n                    enhanced the p53 signaling pathway by blocking the ubiquitination and degradation of p53 and ultimately inhibited neovascularization, a process potentially linked to its direct interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP K). Our findings position MSC\u2010derived exosomes enriched with\n                    <jats:italic>lnc\u2010AGT\u20103<\/jats:italic>\n                    as an innovative therapeutic paradigm for nAMD, acting through\n                    <jats:italic>p53<\/jats:italic>\n                    pathway modulation to potentially overcome current treatment limitations.\n                  <\/jats:p>","DOI":"10.1111\/acel.70377","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:26:34Z","timestamp":1768220794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MSC<\/scp>\n                    \u2010Derived Exosomal\n                    <i>lnc\u2010AGT\u20103<\/i>\n                    : A Novel Anti\u2010Angiogenic Target in Age\u2010Related Macular Degeneration Through\n                    <i>p53<\/i>\n                    Signaling Pathway"],"prefix":"10.1111","volume":"25","author":[{"given":"Lingjie","family":"Kong","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia and Related Eye Diseases, NHC; Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Han","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia and Related Eye Diseases, NHC; Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Qi","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key Laboratory of Myopia and Related Eye Diseases, NHC; Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital Nanjing Medical University  Nanjing 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