{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:36:04Z","timestamp":1790127364538,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102023\u201003683"],"award-info":[{"award-number":["RGPIN\u20102023\u201003683"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002655","name":"Terry Fox Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Senescent cells accumulate with age and after exposure to various stresses, contributing to chronic diseases and cancer, effects largely driven by the senescence\u2010associated secretory phenotype (SASP). Recent evidence indicates that a subset of senescent cells exhibits immunogenic properties. However, the extent to which immunogenicity depends on the cell type and the senescence inducer remains unclear. In this study, we evaluated the immunogenic properties of various human cell types induced to senesce following exposure to ionizing radiation (IR) or oncogenic RAS. Specifically, we used human dermal fibroblasts (HDF) and induced pluripotent stem cell (iPSC)\u2010derived myoblasts (i\u2010MB), endothelial cells (i\u2010EC), lung progenitor cells (i\u2010LPC), along with immune cells from autologous donors. Our results showed that cell types exhibit a distinct SASP and express a variety of inhibitory immune ligands. Notably, senescent HDF displayed a unique immunopeptidome but failed to elicit specific immune responses from CD8+ T cells or NK cells. Similarly, senescent i\u2010EC and i\u2010LPC exhibited limited immunogenicity. In contrast, RAS\u2010induced senescent myoblasts demonstrated immunogenicity, characterized by T cell activation, NK cell\u2010mediated cytotoxicity, and immune cell recruitment in an orthotopic humanized mouse model. These findings highlight the influence of cell type and senescence inducer on immunogenicity and suggest that targeted strategies will be necessary to address the deleterious consequences of the accumulation of distinct senescent cell types.<\/jats:p>","DOI":"10.1111\/acel.70410","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:46:15Z","timestamp":1770957975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type"],"prefix":"10.1111","volume":"25","author":[{"given":"Marie\u2010Lyn","family":"Goyer","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU Sainte\u2010Justine  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de Pharmacologie et Physiologie Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec 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Research in Immunology and Cancer (IRIC) Universit\u00e9 de Montreal  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean V.","family":"Guimond","sequence":"additional","affiliation":[{"name":"CIUSSS du Centre\u2010Sud\u2010de\u2010L'ile\u2010de\u2010Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Haddad","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Sainte\u2010Justine  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de Microbiologie Immunologie et Infectiologie, Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de p\u00e9diatrie, CHU Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec 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