{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:38:00Z","timestamp":1787751480024,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170762"],"award-info":[{"award-number":["32170762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170327"],"award-info":[{"award-number":["82170327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370332"],"award-info":[{"award-number":["82370332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771520"],"award-info":[{"award-number":["31771520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92149302"],"award-info":[{"award-number":["92149302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072331"],"award-info":[{"award-number":["82072331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271265"],"award-info":[{"award-number":["82271265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["19JCJQJC63500"],"award-info":[{"award-number":["19JCJQJC63500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCZDJC00270"],"award-info":[{"award-number":["23JCZDJC00270"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["24JCQNJC00820"],"award-info":[{"award-number":["24JCQNJC00820"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCZDJC00510"],"award-info":[{"award-number":["25JCZDJC00510"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Telomere shortening is a hallmark of aging and has been implicated in cardiovascular disease, but its mechanistic link to atrial fibrillation (AF) remains elusive. Using a high\u2010throughput, single\u2010gene\u2010calibrated dot blot assay, we developed to quantify leukocyte telomere length (LTL). In age\u2010stratified analyses, shorter LTL was associated with AF predominantly in individuals younger than 70\u2009years. In telomerase\u2010deficient (\n                    <jats:italic>TERT<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice with telomere dysfunction, higher AF inducibility, atrial electrical conduction slowing, and atrial fibrosis were observed. Transcriptomic profiling revealed significant alterations in extracellular matrix and cell adhesion pathways in response to telomere dysfunction. Subsequent validation identified vascular cell adhesion molecule\u20101 (VCAM\u20101) as a potential mediator linking telomere shortening to AF\u2010related atrial remodeling. Functional inhibition of VCAM\u20101 reversed electrophysiological abnormalities, attenuated atrial fibrosis, normalized ECM gene expression\u2014including Col1\u03b11, \u03b1\u2010SMA, and CD168\u2014and reduced AF susceptibility by 30%. These findings establish a telomere\u2013VCAM\u20101 axis that drives atrial remodeling and arrhythmogenesis in aging, and position VCAM\u20101 as a candidate therapeutic target for age\u2010related AF.\n                  <\/jats:p>","DOI":"10.1111\/acel.70417","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:49:10Z","timestamp":1770990550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Telomere Shortening Drives Atrial Fibrillation Through\n                    <scp>VCAM<\/scp>\n                    \u20101 Mediated Atrial Electrical and Structural Remodeling"],"prefix":"10.1111","volume":"25","author":[{"given":"Zhaojia","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zandong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"},{"name":"Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province Shulan International Medical College, Zhejiang Shuren University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Song","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Fuyang Biotechnology Co., LTD  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Fuyang Biotechnology Co., LTD  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"},{"name":"School of Nursing and Health Sciences Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Department of Cardiology Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"},{"name":"Tianjin Key Laboratory of Cellular and Molecular Immunology  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051923"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100871"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18935"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-019-00331-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-017-0632-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi825"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121503"},{"key":"e_1_2_10_9_1","article-title":"Cell Adhesion Molecules in Fibrotic Diseases","volume":"11","author":"Hu Q.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.019893"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2016.12.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz648"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.02251"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140263.20897.42"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867331666230822152350"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003525"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032213"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02241-w"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.2.B85"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad130"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.5886"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1058268"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001781"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320608"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322984"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006541"},{"key":"e_1_2_10_29_1","first-page":"625","article-title":"New Aspects of Pathogenesis of Atrial Fibrillation: Remodelling of Intercalated Discs","volume":"66","author":"Tribulova N.","year":"2015","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.019"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.04.033"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0064"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.825459"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891570"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22599"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101707"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:33:16Z","timestamp":1773001996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/acel.70417"],"URL":"https:\/\/doi.org\/10.1111\/acel.70417","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70417"}}