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However, the underlying mechanisms of the frailty remain unknown. In this study, a unique population of hyperactive GAL\u20109\n                    <jats:sup>high<\/jats:sup>\n                    neutrophils is identified with characteristics of elevated ROS, NETs, and IFN\u2010\u03b3, prolonged lifespan, etc. These neutrophils infiltrate into multiple organs to induce injuries, also disrupt the bone marrow microenvironment, drive sustained bone marrow myeloid\u2010biased differentiation, and resist clearance by bone marrow macrophages, serving as a crucial factor to exacerbate frailty. GAL\u20109 protein is demonstrated to play a vital role in the regulation of neutrophil hyperactivity. EccDNA shedding after skin radiation injury is shown to activate the JAK1\/2\u2010STAT1 pathway in splenic GMP cells, which is a potential origin of GAL\u20109\n                    <jats:sup>high<\/jats:sup>\n                    neutrophils. In summary, our results highlight the significance of the previously unrecognized hyperactive GAL\u20109\n                    <jats:sup>high<\/jats:sup>\n                    neutrophils to exacerbate frailty through a \u2018skin\u2010spleen\u2010bone marrow\u2010multiple organs\u2019 axis after local radiation injury.\n                  <\/jats:p>","DOI":"10.1111\/acel.70448","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:20:59Z","timestamp":1775618459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Galectin\u20109\n                    <sup>high<\/sup>\n                    Neutrophils Exacerbate Radiation\u2010Induced Frailty"],"prefix":"10.1111","volume":"25","author":[{"given":"Zhuo","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University  Chongqing 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