{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:00:09Z","timestamp":1788490809441,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R15AG068957"],"award-info":[{"award-number":["R15AG068957"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG068635"],"award-info":[{"award-number":["P30AG068635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56AG06985"],"award-info":[{"award-number":["R56AG06985"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG084180,R01AG079525,R01AG072513"],"award-info":[{"award-number":["R01AG084180,R01AG079525,R01AG072513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG076075"],"award-info":[{"award-number":["R01AG076075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Age\u2010related cellular changes negatively impact CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60\u201380\u2009years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL\u201017A\/F and IL\u201021, and the Th\u201017\u2010supportive cytokine IL\u20106, compared to T cells from younger (Y) adults (25\u201340\u2009years old). The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine production. CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells were isolated from lean normoglycemic younger (avg: 31.58\u2009years; BMI 21.14\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and older (avg: 64.81\u2009years; BMI 21.95\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) adults. SDH was pharmacologically and genetically modulated, and mitochondrial structure, function, metabolites, and cytokine production were quantified. SDH activation in T cells from older adults induced heightened oxidation of succinate, disrupted the fumarate\u2010to\u2010succinate ratio, stabilized HIF\u20101\u03b1, and promoted Th17 cytokines. Genetic and pharmacological inhibition of SDH in T cells from older adults lowered proinflammatory cytokine production, whereas exogenous addition of cell\u2010permeable succinate induced SDH protein in T cells from younger adults and recapitulated the proinflammatory Th17 profile observed in T cells from older adults. These data establish a mechanistic link between SDH and Th17 inflammation.\n                  <\/jats:p>","DOI":"10.1111\/acel.70451","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:17:55Z","timestamp":1774379875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of Succinate Dehydrogenase in Age\u2010Related Th17 Inflammation"],"prefix":"10.1111","volume":"25","author":[{"given":"Evelyn","family":"Ocegueda","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Nutrition Merrimack College  North Andover Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Chase","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Merrimack College  North Andover Massachusetts 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Merrimack College  North Andover Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolander","family":"Valentine","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah J.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Athletic Training University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude T.","family":"Deeney","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, Nutrition &amp; Weight Management Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine S.","family":"Modica\u2010Napolitano","sequence":"additional","affiliation":[{"name":"Department of Natural 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