{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:02:53Z","timestamp":1781024573032,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501263"],"award-info":[{"award-number":["82501263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970783"],"award-info":[{"award-number":["81970783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cataract is a leading cause of visual impairment worldwide, and its prevalence is increasing with population aging. The majority are age\u2010related cataracts (ARC), clinically classified into nuclear, cortical, and posterior subcapsular cataracts (PSC) by opacity location. Mechanisms of cataractogenesis remain incompletely understood. While cortical and nuclear cataracts are largely attributed to crystallin aggregation, such protein\u2010centric mechanisms fail to explain the early onset and axial location of PSC. Morphologically, PSC resembles posterior capsule opacification (PCO), a secondary cataract driven by epithelial\u2013mesenchymal transition (EMT) of lens epithelial cells (LECs), suggesting LEC\u2010EMT may also contribute to PSC. Using clinically stratified human lens samples, we confirmed EMT marker expression across PSC subtypes. Transcriptomic profiling revealed that LECs, the lens's sole metabolically active cells, in age\u2010related PSC (ARC\u2010PSC), compared with age\u2010related nuclear cataract (ANC) and clear lenses, exhibit elevated EMT signatures tightly linked to senescence\u2010associated inflammatory signaling. Aqueous humor (AqH) profiling demonstrated a pro\u2010inflammatory milieu across PSC subtypes, with IL\u201017A uniquely elevated in ARC\u2010PSC, consistent with transcriptomic findings. Integrated analyses support a model in which senescence functions as an upstream driver, whereby senescent LECs release SASP factors, including IL\u201017A, that activate NF\u2010\u03baB signaling to amplify inflammation, reinforce senescence, and drive EMT. In\u00a0vitro, senolysis and IL\u201017A blockade disrupted this loop, attenuating senescence\u2010 and EMT\u2010associated phenotypes. Collectively, our study demonstrates that senescent LECs sustain an IL\u201017A\u2013NF\u2010\u03baB circuit that drives EMT and accelerates ARC\u2010PSC progression, positioning ARC\u2010PSC as a unique human context to study senescence\u2010induced epithelial remodeling in aging tissues.<\/jats:p>","DOI":"10.1111\/acel.70456","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:45:43Z","timestamp":1774410343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Senescence\u2010Driven\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>17A<\/scp>\n                    Inflammatory Circuit Promotes Epithelial\u2013Mesenchymal Transition (\n                    <scp>EMT)<\/scp>\n                    and Progression in Age\u2010Related Posterior Subcapsular Cataracts"],"prefix":"10.1111","volume":"25","author":[{"given":"Yan","family":"Ni","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 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