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Recent research highlights the vital role of miR\u2010128\u20103p in osteoclast (OC) differentiation and the progression of osteoporosis following ovariectomy. Nonetheless, the mechanism by which miR\u2010128\u20103p influences osteoblast (OB)\u2010mediated bone formation and contributes to bone loss associated with aging is poorly understood. The present investigation began with an analysis of human bone samples, in which we observed that the age\u2010related miR\u2010128\u20103p increase was negatively correlated with bone formation. In addition, miR\u2010128\u20103p expression decreased during OB differentiation. Next, we found that OB miR\u2010128\u20103p conditional deletion (\n                    <jats:italic>cKO, miR\u2010128\u20103p<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Ob\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ) markedly increased bone mass by increasing bone formation. We also revealed that global knockout of miR\u2010128\u20103p (\n                    <jats:italic>KO<\/jats:italic>\n                    , miR\u2010128\u20103p\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) controlled skeletal homeostasis. Further in\u00a0vitro studies confirmed that miR\u2010128\u20103p deletion in OBs stimulates osteoblastogenesis; its inhibition in MC3T3\u2010E1 cells gave similar results. Mechanistically, miR\u2010128\u20103p regulated osteoblastogenesis via disheveled\u20102 (Dvl2)\u2010mediated canonical Wnt signaling. Finally, osteoblastic miR\u2010128\u20103p deficiency prevented age\u2010related bone loss in mice. In summary, our results establish the role of miR\u2010128\u20103p in OB differentiation and bone formation, thereby providing insight into potential diagnostic and therapeutic targets in age\u2010related osteoporosis.\n                  <\/jats:p>","DOI":"10.1111\/acel.70460","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:46:31Z","timestamp":1774669591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MicroRNA<\/scp>\n                    \u2010128\u20103p Deficiency Alleviates Bone Loss in Age\u2010Related Osteoporosis via Activation of Canonical Wnt Signaling"],"prefix":"10.1111","volume":"25","author":[{"given":"Gengyang","family":"Shen","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou Medical University  Guangzhou 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of Chinese Medicine  Guangzhou China"},{"name":"Lingnan Medical Research Center of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Lingnan Medical Research Center of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-5726","authenticated-orcid":false,"given":"Jiahui","family":"He","sequence":"additional","affiliation":[{"name":"The Affiliated TCM Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou Medical University  Guangzhou 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