{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:02:58Z","timestamp":1781024578448,"version":"3.54.1"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271176"],"award-info":[{"award-number":["82271176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271172"],"award-info":[{"award-number":["82271172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471174"],"award-info":[{"award-number":["82471174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700918"],"award-info":[{"award-number":["81700918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192861"],"award-info":[{"award-number":["82192861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211357"],"award-info":[{"award-number":["tsqn202211357"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Noise exposure is a known cause of hearing loss, and only a few effective preventive drugs are available. Therefore, in this study, we aimed to investigate the protective effects of brimonidine on noise\u2010induced inner ear hearing impairment in mice and explore its underlying mechanisms and long\u2010term outcomes. Mice were randomly divided into control, noise exposure, and brimonidine groups. A 62\u2010week follow\u2010up was conducted after noise exposure. Brimonidine inhibited the noise\u2010induced increase in inner ear glutamate concentration and downregulated inflammatory factors and immunoglobulins. Brimonidine decreased glutaminase and VGLUT2\/3 expression and reduced glutamate synthesis and vesicle transport without affecting its clearance, thereby decreasing glutamate excitotoxicity and protecting synapses and spiral ganglion neurons long term. Mice exposed to noise could temporarily restore their hearing thresholds; however, their auditory function in old age remained significantly worse than those that received brimonidine\u2010mediated cochlear protection in youth. These findings highlight the importance of enhancing noise protection from an early age.<\/jats:p>","DOI":"10.1111\/acel.70481","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:55:28Z","timestamp":1775724928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brimonidine Therapy for Protection From Noise\u2010Induced Hearing Loss"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-2803","authenticated-orcid":false,"given":"Jing","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-1258","authenticated-orcid":false,"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daogong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-6042","authenticated-orcid":false,"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-9532","authenticated-orcid":false,"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5338\u201005.2006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023\u2010063753"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010021\u201001516\u20101"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.02.016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.10.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1904407"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.21.285643"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08\u20102078"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2025.104345"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5138\u201014.2015"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.016"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20105955(99)00223\u20103"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.08.011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1545\u201006.2006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000759"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201051724\u20106"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.04.011"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010018\u201000691\u20102"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914247117"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280018"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S453417"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.08.035"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010008\u20109633\u20109"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050218"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2228\u201018.2019"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035493"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4985\u201005.2006"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845\u201009.2009"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.02.009"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4914\u201007.2008"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200201000\u201000026"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0166"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047098"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2022.2112948"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010015\u20100510\u20103"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.01.003"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010011\u20100277\u20100"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0308671"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001874"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010011\u20100283\u20102"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000939R"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.11.007"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.013"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.10"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx081"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6708a2"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.397"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.07.005"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081188"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.756449"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.09.010"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735\u2010199804000\u201000006"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.877588"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409322"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17101261"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2007.20.3.1084644"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00106"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004268\u20104"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3238\u201020.2021"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.04.010"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11049"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:48:20Z","timestamp":1781023700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/acel.70481"],"URL":"https:\/\/doi.org\/10.1111\/acel.70481","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70481"}}