{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:39:48Z","timestamp":1793014788649,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["S\u2010PD\u201024\u201095"],"award-info":[{"award-number":["S\u2010PD\u201024\u201095"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share metabolic and inflammatory mechanisms, potentially mediated by the gut microbiota, yet the neurobiological impact of comorbid AD+T2DM microbiota from elderly donors remains unexplored. Fecal microbiota from healthy, AD, T2DM, and AD+T2DM postmenopausal female donors (aged 56\u201389\u2009years) was transplanted into antibiotic\u2010treated male mice. Behavioral testing, blood profiling, hippocampal neurotrophic gene expression, and 16S rRNA sequencing with taxonomic, functional, and metabolic analyses were performed. Human AD+T2DM microbiota displayed the greatest dysbiosis, characterized by enrichment of pro\u2010inflammatory taxa, depletion of butyrate\u2010producing genera, and loss of neuroprotective metabolic pathways. FMT induced robust engraftment, with AD+T2DM recipients diverging most from controls (PERMANOVA\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.209,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and healthy recipients (PERMANOVA\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.111,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Donor age contributed significantly to recipient microbiota variation (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.028,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), suggesting transmission of aging\u2010associated microbial signatures. Hippocampal neurotrophic gene expression was most suppressed in AD+T2DM recipients (adjusted\n                    <jats:italic>p<\/jats:italic>\n                    value &lt;\u20090.05) and negatively correlated with disease\u2010 and aging\u2010associated taxa and microbial functions (|r|\u2009&gt;\u20090.4, FDR\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). AD recipients showed reduced olfactory discrimination and increased daytime locomotor activity. Metabolic network analysis revealed depletion of flavonoid, isoflavonoid, and lignan biosynthesis pathways in disease recipients. These findings suggest that microbiota from elderly donors with comorbid AD+T2DM may induce gut\u2013brain axis alterations, linking aging, metabolic dysfunction, and neurodegeneration through convergent taxonomic, functional, and neurotrophic changes. We underscore the potential role of age\u2010associated gut microbial signatures in modulating neurobiological outcomes.\n                  <\/jats:p>","DOI":"10.1111\/acel.70488","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:09:56Z","timestamp":1776830996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comorbid Alzheimer's Disease and Type 2 Diabetes Microbiota Shape Age\u2010Associated Gut\u2013Brain Axis Profiles"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-8606","authenticated-orcid":false,"given":"Alessandro","family":"Atzeni","sequence":"first","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Mingaila","sequence":"additional","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gediminas","family":"Alzbutas","sequence":"additional","affiliation":[{"name":"Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokas","family":"Luko\u0161evi\u010dius","sequence":"additional","affiliation":[{"name":"Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justinas","family":"Dr\u016bteika","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lithuanian University of Health Sciences Hospital of Lithuanian University of Health Sciences Kauno Klinikos  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"\u0141uczy\u0144ska","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences  Magdalenka Poland"},{"name":"The Second Department of Psychiatry, Institute of Psychiatry and Neurology in Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Ramonait\u0117","sequence":"additional","affiliation":[{"name":"Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Pietras","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Sipowicz","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Research in the Area of Social Inclusion The Maria Grzegorzewska University  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovil\u0117","family":"Kiudelyt\u0117","sequence":"additional","affiliation":[{"name":"Dr. L. Kriau\u010deli\u016bnas Small Animal Clinic, Faculty of Veterinary, Veterinary Academy Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Ker\u0161yt\u0117","sequence":"additional","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Ke\u017eevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Naj\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lithuanian University of Health Sciences Hospital of Lithuanian University of Health Sciences Kauno Klinikos  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-7416","authenticated-orcid":false,"given":"Juozas","family":"Kup\u010dinskas","sequence":"additional","affiliation":[{"name":"Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas Lithuania"},{"name":"Gastroenterology Department Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-3815","authenticated-orcid":false,"given":"Jordi","family":"Mayneris\u2010Perxachs","sequence":"additional","affiliation":[{"name":"Integrative Systems Medicine and Biology Institut d'Investigaci\u00f3 Biom\u00e8dica de Girona Dr. Josep Trueta (IDIBGI)  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-9270","authenticated-orcid":false,"given":"Daiva","family":"Baltriukien\u0117","sequence":"additional","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-3496","authenticated-orcid":false,"given":"Aurelijus","family":"Burokas","sequence":"additional","affiliation":[{"name":"Department of Biological Models, Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323071"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1982.tb01195.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.09.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323371"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325753"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.02.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.052"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010018\u20100048\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10062"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2015.02.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"265","article-title":"Nonparametric Estimation of the Number of Classes in a Population","volume":"11","author":"Chao A.","year":"1984","journal-title":"Scandinavian Journal of Statistics"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00383"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043167\u20105"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062099"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16101460"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107988"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30356\u20104"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0324712"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200619"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103293"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02873\u20100"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/672295"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00397"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02430"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20102618\u20102\u20106"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00061"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.8.1108"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010021\u201004267\u20105"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.10.006"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16244405"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/BPL\u2010220141"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020436"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2100197"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001964\u20103"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzac107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01208"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010024\u201003195\u20104"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010708594"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.101034"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30231\u20103"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2302801"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010317431"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.09.002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2419565"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1617980"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010024\u201001944\u20104"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12760"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.833269"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1184734"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201017041\u20107"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1635579"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922392117"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(02)00828\u20100"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.138198.112"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.04.001"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1279354"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010037"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116097"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512005"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.11.001"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4968"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112549"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.757718"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70154"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201013722\u20104"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.03.020"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/16512235.2017.1353881"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010017\u20101445\u20108"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1474043"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.07.008"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001913\u20100"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1979878"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538\u20107305.1948.tb01338.x"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/163688a0"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010171042"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102005\u20107107"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.047"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59903"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.611014"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs012"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010018\u20100337\u2010x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89862"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.88"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.08.022"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102881\u20109"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4622\u201009.2010"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1065668"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.11.009"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.785644"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.13527"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20100460.1000177"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180176"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:19:54Z","timestamp":1779401994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":102,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/acel.70488"],"URL":"https:\/\/doi.org\/10.1111\/acel.70488","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2025-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70488"}}