{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:53Z","timestamp":1787013773725,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK125922"],"award-info":[{"award-number":["1R01DK125922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging\u2010associated changes in myeloid cells are incompletely understood. One of the culprits of aging is the downregulation of the\n                    <jats:italic>Tert<\/jats:italic>\n                    gene coding for the catalytic subunit of telomerase. Studies of mouse models with\n                    <jats:italic>Tert<\/jats:italic>\n                    knockout (KO) in specific cells have revealed the importance of the telomere\u2010independent noncanonical function of TERT in supporting mitochondrial metabolism and protection from cell senescence. To investigate the role of TERT in myeloid cells (MCs), we analyzed mice with\n                    <jats:italic>Tert<\/jats:italic>\n                    KO in the LysM+ lineage, indelibly labeled with membrane green fluorescent protein (mG). Macrophage numbers and properties in various organs were compared. Changes in the vasculature, adipose tissue (AT) depots, lungs, heart, and other tissues were assessed. MC\u2010\n                    <jats:italic>Tert\u2010<\/jats:italic>\n                    KO mice displayed MC depletion in the bone marrow and abnormal frequencies in other organs.\n                    <jats:italic>Tert\u2010<\/jats:italic>\n                    KO MCs were found to express senescence markers despite having a normal telomere length.\n                    <jats:italic>Tert<\/jats:italic>\n                    \u2010KO macrophages were found to be polarized toward the pro\u2010inflammatory M1 phenotype, upregulate expression of genes promoting lipid uptake and retention, and be prone to conversion into foam cells. MC\u2010\n                    <jats:italic>Tert\u2010<\/jats:italic>\n                    KO mice fed a high\u2010calorie diet had increased adiposity and dysfunctional glucose metabolism. On an atherogenic diet, MC\u2010\n                    <jats:italic>Tert\u2010<\/jats:italic>\n                    KO mice displayed abnormal lipid metabolism and chronic fever. Aged MC\u2010\n                    <jats:italic>Tert\u2010<\/jats:italic>\n                    KO mice developed pulmonary fibrosis and an imbalance in right\/left ventricle cardiac output. Our results show that the increased conversion of\n                    <jats:italic>Tert<\/jats:italic>\n                    \u2010KO MCs into foam cells leads to systemic organ dysfunction. We conclude that TERT plays an important noncanonical function in MCs that prevents the development of aging\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1111\/acel.70490","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:21:12Z","timestamp":1776399672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction"],"prefix":"10.1111","volume":"25","author":[{"given":"Zhanguo","family":"Gao","sequence":"first","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Yu","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wiggins","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Sevick\u2010Muraca","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-7869","authenticated-orcid":false,"given":"Mikhail G.","family":"Kolonin","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqac043"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051923"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311054"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201004\u20101386"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010021\u201008909\u20107"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024853118"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3791\/61277"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008942828960"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1446964"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.148"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.05.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.616200"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11121768"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.044922"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u201000320\u20104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.155861"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21\u20100972"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14138"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1295072"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14499"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201002006\u20105"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00182"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010021\u201000797\u20102"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142547"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162152"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab547"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20335"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010081022\u2010113627"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1480\u20109222\u201013\u20103"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007475"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000894\u2010y"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010018\u20104496\u2010x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.206268"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09787"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08982"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.008"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.01.008"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.0720"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042980"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003547\u20107"}],"updated-by":[{"DOI":"10.1111\/acel.70619","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000}}],"container-title":["Aging 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