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Here, we combined transcriptomic and metabolomic profiling of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    <\/jats:styled-content>\n                    to investigate how short\u2010term, long\u2010term, and recovery phases of stress exposure shape cellular physiology and lifespan. Short\u2010term stress\u2010induced protective pathways and longevity\u2010associated metabolites, including trehalose and 5\u2032\u2010methylthioadenosine, consistent with enhanced stress resilience and proteostasis. In contrast, prolonged stress activated heat shock proteins and epigenetic regulators, coupled with metabolic signatures associated with loss of proteostasis, reduced energy homeostasis, and shortened chronological lifespan. Upon recovery, beneficial metabolites such as S\u2010adenosylhomocysteine were restored, highlighting the reversibility of stress\u2010induced aging trajectories. Phylogenetic analysis demonstrated conservation of these stress\u2010 and aging\u2010related genes across eukaryotes and prokaryotes, suggesting an evolutionary basis for aging as a long\u2010term stress adaptation. Together, these findings suggest that aging\u2010associated molecular changes are closely linked to conserved stress response pathways, with implications for understanding the hallmarks of aging.\n                  <\/jats:p>","DOI":"10.1111\/acel.70513","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:36:27Z","timestamp":1777098987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Stress Adaptation as a Highly\u2010Conserved Key Factor in Yeast Aging"],"prefix":"10.1111","volume":"25","author":[{"given":"Yanzhuo","family":"Kong","sequence":"first","affiliation":[{"name":"College of Food and Chemical Engineering Shaoyang University  Shaoyang China"},{"name":"Faculty of Agriculture and Life Sciences Lincoln University  Lincoln New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damola","family":"Adejoro","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Life Sciences Lincoln University  Lincoln New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Winefield","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Life Sciences Lincoln University  Lincoln New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L. 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