{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:14:45Z","timestamp":1779405285438,"version":"3.53.1"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM136348"],"award-info":[{"award-number":["R35GM136348"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2445150"],"award-info":[{"award-number":["2445150"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD007470"],"award-info":[{"award-number":["T32HD007470"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The ovary is one of the first organs to lose functionality with age. We found that aging of the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    ovary is characterized by an accumulation of phenotypes in the somatic compartment, including failure of the follicle cells to encapsulate germ\u2010cell cysts, an extended S phase, and increased DNA damage. In aged ovaries, follicle encapsulation defects are associated with the lack of a germ\u2010cell cyst checkpoint in early oogenesis. Single\u2010cell RNA sequencing revealed that, across all cell types in the ovary, cells in the follicle lineage have the highest number of differentially expressed genes. Overexpression of\n                    <jats:italic>Atg8a<\/jats:italic>\n                    , a key autophagy machinery gene homologous to mammalian LC3, specifically in follicle cells prevents age\u2010associated decline in the follicle epithelium and loss of reproductive capacity. Collectively, these findings demonstrate that genetic manipulation of a small population of ovarian somatic cells is sufficient to improve both cell\u2010autonomous and non\u2010autonomous features of reproductive aging.\n                  <\/jats:p>","DOI":"10.1111\/acel.70529","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:42:01Z","timestamp":1777606921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Decline in Follicle Cell Function Is a Major Driver of\n                    <i>Drosophila<\/i>\n                    Ovarian Aging"],"prefix":"10.1111","volume":"25","author":[{"given":"Emily A.","family":"Wolfgram","sequence":"first","affiliation":[{"name":"Department of Anatomy UCSF  San Francisco California USA"},{"name":"Bakar Aging Research Institute UCSF  San Francisco California USA"},{"name":"Broad Center of Regeneration Medicine and Stem Cell Research UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-2394","authenticated-orcid":false,"given":"Todd G.","family":"Nystul","sequence":"additional","affiliation":[{"name":"Department of Anatomy UCSF  San Francisco California USA"},{"name":"Bakar Aging Research Institute UCSF  San Francisco California USA"},{"name":"Broad Center of Regeneration Medicine and Stem Cell Research UCSF  San Francisco California USA"},{"name":"Department of OB\u2010GYN\/RS UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.170077bs"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00769-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.157"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.05.025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26952"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.08.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9863"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot087221"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16022641"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00545"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599086"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.11.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0135"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57901-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13050775"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0037-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adx0659"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112351"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08619"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-03-0205"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.08.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2019.11.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00762-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-007-0009-3"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12288"},{"key":"e_1_2_11_29_1","first-page":"121","article-title":"Oogenesis in Adult \n                     Drosophila melanogaster","volume":"20","author":"King R. 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