{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:17Z","timestamp":1782938777990,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005762"],"award-info":[{"award-number":["I01BX005762"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6BX006467"],"award-info":[{"award-number":["IK6BX006467"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG066729"],"award-info":[{"award-number":["R01AG066729"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS0064131"],"award-info":[{"award-number":["R01NS0064131"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG066509"],"award-info":[{"award-number":["P30AG066509"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG066567"],"award-info":[{"award-number":["U19AG066567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders. Identifying new strategies to treat tauopathy remains an important gap in the field. Using forward and reverse genetic approaches in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , we identified\n                    <jats:italic>smrd\u20101<\/jats:italic>\n                    , the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    homolog of\n                    <jats:italic>SMARCAD1<\/jats:italic>\n                    , as a potent modifier of tauopathy phenotypes in a transgenic model of tauopathy. Loss of\n                    <jats:italic>smrd\u20101<\/jats:italic>\n                    function rescues tauopathy\u2010associated neuronal dysfunction and neurodegeneration in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    models of tauopathy. Loss or reduction of\n                    <jats:italic>smrd\u20101\/SMARCAD1<\/jats:italic>\n                    decreases phosphorylated and total tau protein levels by reducing tau mRNA transcripts in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    and mammalian HEK\u2010tau cells. Loss of\n                    <jats:italic>smrd\u20101<\/jats:italic>\n                    rescues tau\u2010driven abnormal H3K9me3 chromatin methylation. Immunohistochemistry in human postmortem AD brain tissue showed SMARCAD1 depletion in a subset of cases that also exhibit depletion of MSUT2. Loss of\n                    <jats:italic>smrd\u20101\/SMARCAD1<\/jats:italic>\n                    rescues tau\u2010mediated neurodegeneration via a tau mRNA lowering mechanism accompanied by changes in chromatin conformation.\n                  <\/jats:p>","DOI":"10.1111\/acel.70543","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:16:41Z","timestamp":1779941801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of\n                    <scp>SMARCAD1<\/scp>\n                    Mitigates Tauopathy"],"prefix":"10.1111","volume":"25","author":[{"given":"Vaishnavi S.","family":"Jadhav","sequence":"first","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Kow","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia D.","family":"Beale","sequence":"additional","affiliation":[{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Baum","sequence":"additional","affiliation":[{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin S.","family":"Latimer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Mental Illness Research, Education, and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole F.","family":"Liachko","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-7634","authenticated-orcid":false,"given":"Brian C.","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine, Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System  Seattle Washington USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Genome Sciences University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2016.1195059"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103791"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx243"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300625"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2362"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20105949.2009.00115.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.03.016"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383\u20105718(01)00198\u2010X"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301532"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2207250120"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3639"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathmechdis\u2010012418\u2010012936"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010011\u20109502\u2010x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp099"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072\u2010019\u20100289\u20102"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad049"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105148"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm143"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533448100"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237\u2010017\u20100221\u20108"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00321"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13153"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(02)02228\u20107"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe7804"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039218\u2010x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.179382"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.740550"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.02.036"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009078\u20100"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.87742"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac194"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.02.006"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157651.113"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201012070\u20103"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao6545"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.070"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010024\u201001465\u20106"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:27:52Z","timestamp":1782937672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/acel.70543"],"URL":"https:\/\/doi.org\/10.1111\/acel.70543","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70543"}}