{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:15Z","timestamp":1782938775081,"version":"3.54.5"},"reference-count":77,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2008002"],"award-info":[{"award-number":["2020YFC2008002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300420181"],"award-info":[{"award-number":["262300420181"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Arterial stiffness is a hallmark of vascular aging and a major risk factor for cardiovascular disease. While immune aging\u2014typically characterized by reduced T cell receptor (TCR) diversity and CD8\n                    <jats:sup>+<\/jats:sup>\n                    memory expansion\u2014contributes to this process, growing evidence suggests that peripheral immune dysregulation may impair vascular function through mechanisms distinct from classical immunosenescence. To investigate this, we profiled peripheral TCR\u03b2 repertoires from 563 adults without clinically overt cardiovascular disease and assessed their association with pulse wave velocity (PWV), a gold\u2010standard marker of arterial stiffness. Surprisingly, individuals with elevated PWV exhibited a paradoxical increase in TCR diversity, driven by broad remodeling of numerous low\u2010frequency CD4\n                    <jats:sup>+<\/jats:sup>\n                    clonotypes that preferentially mapped to a naive\u2010like\/early\u2010differentiation CD4\n                    <jats:sup>+<\/jats:sup>\n                    compartment. Single\u2010cell transcriptomic analyses further indicated chronic activation, proliferative restraint, and dysfunctional immune states in these PWV\u2010associated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Furthermore, a machine learning model trained on these PWV\u2010associated repertoire features accurately identified individuals with high PWV (AUC\u2009=\u20090.817), suggesting potential utility in subclinical vascular risk stratification. These findings define a distinct, CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013driven immune remodeling process\u2014termed \u201cvascular immune remodeling\u201d\u2014that is dissociable from classical immunosenescence and may contribute to arterial stiffening, uncovering an unexpected immune trajectory in early vascular aging and offering new avenues for immune\u2010based vascular risk assessment and intervention.\n                  <\/jats:p>","DOI":"10.1111\/acel.70568","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:47:15Z","timestamp":1780559235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vascular Immune Remodeling: A\n                    <scp>CD4<\/scp>\n                    <sup>+<\/sup>\n                    T Cell\u2013Driven Immune Trajectory Associated With Arterial Stiffness"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4565-674X","authenticated-orcid":false,"given":"Yu","family":"Miao","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research, Henan Academy of Sciences  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangwei","family":"Chen","sequence":"additional","affiliation":[{"name":"BGI Genomics  Shenzhen China"},{"name":"Department of Geriatrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research, Henan Academy of Sciences  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tongji Hospital, Tongji Medical 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