{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:13Z","timestamp":1782938773246,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG052419"],"award-info":[{"award-number":["R01AG052419"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG021332"],"award-info":[{"award-number":["P30AG021332"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F31AA032409"],"award-info":[{"award-number":["F31AA032409"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001420"],"award-info":[{"award-number":["UL1TR001420"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013142","name":"Translational Science Center, Wake Forest University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Life is a constant struggle against disorder. As we age, our ability to maintain internal order declines. In the healthy human brain, order is observable in the form of functionally segregated brain network communities that exhibit spatial consistency. These communities associate with distinct cognitive and physical functions. When mapped into the brain, they form a functional \u201clandscape\u201d. We assessed the spatial disorder of these landscapes in older adults with a wide range of mobility using a spatial form of Shannon entropy. We found that compared to younger adults, older adults had significantly higher entropy in the sensorimotor cortex, basal ganglia, hippocampus, thalamus, and occipital lobe. Higher entropy in many of these regions was associated with worse physical function and higher body mass index in older adults. Findings suggest that spatial entropy in brain network landscapes may be a marker of declining physical function. Modifiable factors, such as losing excess weight, may help to ameliorate aging\u2010related brain entropy increases in regions such as the sensorimotor cortex, which may in turn help to preserve physical function in older adults.<\/jats:p>","DOI":"10.1111\/acel.70596","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:04:35Z","timestamp":1781798675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-9453","authenticated-orcid":false,"given":"Clayton C.","family":"McIntyre","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program Wake Forest Graduate School of Arts and Sciences  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2440-8055","authenticated-orcid":false,"given":"Shannon M.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program Wake Forest Graduate School of Arts and Sciences  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Lyday","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-260X","authenticated-orcid":false,"given":"Steven R.","family":"Cummings","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center Sutter Health Research Institute  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Laurienti","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010022\u201000581\u2010w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000154929"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010025\u201001788\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.01.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406293182"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.03.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.8.m428"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2335"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.03.045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2008.02126.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70292"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/23814683231187566"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12056"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28948"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903215107"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000889\u20103"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000240127.89601.83"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw043"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000150\u20103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2003.107"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.m85"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.051"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu048"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq113"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.03.008"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.07.019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaf039"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2011.300361"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.2\/smarek"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","unstructured":"McIntyre C. C. S. M.O'Donnell M.Khodaei R. G.Lyday J. H.Burdette andP. J.Laurienti.2025.\u201cSpatial Entropy of Brain Network Landscapes: A Novel Method to Assess Spatial Disorder in Brain Networks.\u201dbioRxiv.https:\/\/doi.org\/10.1101\/2025.10.23.684130.","DOI":"10.1101\/2025.10.23.684130"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010021\u201001152\u2010w"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000975\u20102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.52294\/001c.140681"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117344"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601602103"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.69.026113"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167\u20108760(97)00754\u2010x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.10.m638"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9868"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2019.11.013"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525x00062713"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/Bf00162741"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2014.03.005"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2024.45"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2025.100652"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010022\u201003123\u20104"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2212776120"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12457"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.11"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538\u20107305.1948.tb01338.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.10.m644"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/864516"},{"key":"e_1_2_10_59_1","volume-title":"Time, Cells, and Aging","author":"Strehler B. L.","year":"1962"},{"key":"e_1_2_10_60_1","unstructured":"The Demographic Outlook: 2025 to 2055.2025.http:\/\/www.cbo.gov\/publication\/60875."},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad060"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201041695\u2010z"},{"key":"e_1_2_10_63_1","first-page":"P25","volume-title":"The Next Four Decades: The Older Population in the United States: 2010 to 2050","author":"Vincent G. K.","year":"2010"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.596122"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117893"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089948"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_10_68_1","volume-title":"Neuroanatomy","author":"Young C. B.","year":"2025"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:26:45Z","timestamp":1782937605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/acel.70596"],"URL":"https:\/\/doi.org\/10.1111\/acel.70596","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70596"}}