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We investigated the protective role of Humanin (HN), a mitochondria\u2010derived peptide with known neuroprotective effects in A\u03b2\u2010related neurodegenerative diseases, in retinal pathology induced by subretinal injection of FITC\u2010labeled A\u03b2. HN enhanced the clearance of A\u03b2\u2010accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. In ARPE\u201019 cells, HN activated AMP\u2010activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria. This process facilitated the removal of A\u03b2\u2010accumulated mitochondria in the RPE. Our results demonstrate that targeting mitophagy in the RPE with HN may offer a promising therapeutic strategy for AMD.<\/jats:p>","DOI":"10.1111\/acel.70601","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:13:55Z","timestamp":1782202435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Humanin Mitigates A\u03b2\u2010Induced Retinal Pigment Epithelium Injury via\n                    <scp>AMPK<\/scp>\n                    \u2010Beclin1\u2010Dependent Mitophagy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9005-1095","authenticated-orcid":false,"given":"Ha Young","family":"Jang","sequence":"first","affiliation":[{"name":"Fight Against Angiogenesis\u2010Related Blindness (FARB) Laboratory, Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Global Excellence Center for Gene &amp; Cell 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