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Although protein\u2010coding regulators have dominated aging research, the contribution of long non\u2010coding RNAs (lncRNAs), particularly primate\u2010specific lncRNAs, has not been systematically explored. Here, through evolutionary screening and cross\u2010species aging\u2010associated analyses, we identified a set of primate\u2010specific lncRNAs (including\n                    <jats:italic>LINC01021<\/jats:italic>\n                    ,\n                    <jats:italic>CTC\u2010575\u2009l10.1<\/jats:italic>\n                    ,\n                    <jats:italic>CTA\u2010150C2.13<\/jats:italic>\n                    , and\n                    <jats:italic>RP11\u2010305F18.1<\/jats:italic>\n                    , etc.) associated with human aging, and we functionally characterized\n                    <jats:italic>LINC01021<\/jats:italic>\n                    as a representative candidate to assess their causal involvement. In human cells,\n                    <jats:italic>LINC01021<\/jats:italic>\n                    promotes cellular senescence, whereas its silencing attenuates senescence\u2010associated phenotypes. Mechanistically,\n                    <jats:italic>LINC01021<\/jats:italic>\n                    is predominantly located in the nucleus, where it facilitates DAZAP1\u2010dependent destabilization of RBMX mRNA, leading to activation of the P53 pathway and induction of canonical senescence features. At the organismal level, ectopic expression of human\n                    <jats:italic>LINC01021<\/jats:italic>\n                    in mice contributes to aging\u2010like phenotypes, including increased frailty and impaired motor coordination. Together, these findings implicate primate\u2010specific lncRNAs in lineage\u2010restricted aging and highlight an evolutionarily recent regulatory layer that may modulate aging trajectories.\n                  <\/jats:p>","DOI":"10.1111\/acel.70603","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:47:27Z","timestamp":1782402447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Primate\u2010Specific\n                    <scp>\n                      lncRNA\n                      <i>LINC01021<\/i>\n                    <\/scp>\n                    Contributes to Cellular and Organismal Aging via\n                    <scp>DAZAP1<\/scp>\n                    \u2010Dependent Destabilization of\n                    <scp>RBMX<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Zi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Nisar","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawar","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology The University of Lahore  Lahore Pakistan"},{"name":"Biodiversity Data Center of Kunming Institute of Zoology Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoxian","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyan","family":"Pu","sequence":"additional","affiliation":[{"name":"Biodiversity Data Center of Kunming Institute of Zoology Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonghua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences  Kunming 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