{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:07:00Z","timestamp":1784610420980,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470744"],"award-info":[{"award-number":["82470744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370681"],"award-info":[{"award-number":["82370681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293641"],"award-info":[{"award-number":["82293641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250158"],"award-info":[{"award-number":["BK20250158"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240050"],"award-info":[{"award-number":["BK20240050"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its molecular drivers remain incompletely defined. Here we identify microsomal prostaglandin E synthase\u20102 (mPGES\u20102) as a critical regulator of renal aging and its skeletal consequence. Genetic ablation of\n                    <jats:italic>Ptges2<\/jats:italic>\n                    improved health indices in aged mice, prolonged median survival, and markedly alleviated glomerulosclerosis, podocyte injury, and renal senescence. Single\u2010cell transcriptomic analysis, together with podocyte\u2010 and tubule\u2010specific knockout models, showed that podocyte mPGES\u20102, rather than tubular mPGES\u20102, is the dominant intrarenal driver of aging\u2010related kidney injury. Mechanistically, mPGES\u20102 promoted podocyte senescence through a PGE\n                    <jats:sub>2<\/jats:sub>\n                    \/EP1 signaling axis. Podocyte\u2010specific\n                    <jats:italic>Ptges2<\/jats:italic>\n                    deletion also mitigated age\u2010related osteoporosis and restored renal calcitriol and \u03b1\u2010klotho, supporting a kidney\u2010bone mechanism secondary to impaired renal endocrine function. Consistent with the genetic models, pharmacological inhibition of mPGES\u20102 with SZ0232 attenuated renal aging and improved bone microarchitecture in aged mice. Both genetic deficiency and pharmacological inhibition of mPGES\u20102 were well tolerated, with no overt adverse effects on major organs. These findings identify podocyte mPGES\u20102 as a druggable determinant of renal aging and a potential therapeutic target for aging\u2010associated osteoporosis.\n                  <\/jats:p>","DOI":"10.1111\/acel.70609","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:28:06Z","timestamp":1782397686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Podocyte\n                    <scp>mPGES<\/scp>\n                    \u20102 Determines Renal Aging and Contributes to Senile Osteoporosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Dandan","family":"Zhong","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Hao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Taicang Loujiang New Town Hospital  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key 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Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-5711","authenticated-orcid":false,"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Ni","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Nanjing Key Laboratory of Pediatrics Children's Hospital of Nanjing Medical University  Nanjing Jiangsu 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