{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:07:23Z","timestamp":1784610443431,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic pruritus (or itch) is a common condition associated with aging; however, the neural mechanisms driving age\u2010related itch hypersensitivity remain largely unknown. Here, we investigated the role of serotonergic signaling in modulating itch sensitivity during aging. Aged mice exhibited enhanced mechanical alloknesis without changes in spontaneous scratching behavior, indicating that aging selectively affects mechanically evoked itch. Consistent with this phenotype, aged mice showed elevated urinary serotonin levels and increased expression of the serotonin receptor 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    in dorsal root ganglion neurons and the spinal dorsal horn. Pharmacological blockade of 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    receptors attenuated itch\u2010related behaviors, particularly mechanical alloknesis, indicating that serotonergic remodeling contributes to age\u2010related itch hypersensitivity. These findings identify spinal 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    signaling as a potential therapeutic target for chronic pruritus in older individuals.\n                  <\/jats:p>","DOI":"10.1111\/acel.70633","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:24:36Z","timestamp":1783999476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging Enhances Serotonergic Signaling via 5\u2010HT\n                    <sub>7<\/sub>\n                    Receptors Underlying Mechanical Alloknesis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7407-4043","authenticated-orcid":false,"given":"Qiaofeng","family":"Zhao","sequence":"first","affiliation":[{"name":"Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender\u2010Specific Medicine Juntendo University  Chiba 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