{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:07:37Z","timestamp":1784610457567,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300892"],"award-info":[{"award-number":["82300892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS1417"],"award-info":[{"award-number":["ZR2025MS1417"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH182"],"award-info":[{"award-number":["ZR2022MH182"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["2024\u2010N\u201005\u201005"],"award-info":[{"award-number":["2024\u2010N\u201005\u201005"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Health problems associated with aging have become increasingly severe in recent years. For example, hepatic lipid metabolism declines as the body ages, leading to lipid metabolic disorders. Although exosomes have been explored for treating metabolic diseases, there is currently a paucity of research regarding aging\u2010related changes in hepatic lipid metabolism. Herein, we cultured human umbilical cord mesenchymal stem cells (HucMSCs), from which we extracted HucMSC\u2010derived exosomes (HucMDEs). We then established a natural aging mouse model in\u00a0vivo and a palmitic acid\u2010induced AML12 cell model in\u00a0vitro; HucMDEs were subsequently used as an intervention. Western blot analysis and quantitative real\u2010time PCR were used to investigate changes in liver lipid metabolism and senescence\u2010related markers in\u00a0vivo and in\u00a0vitro. Our results revealed that the HucMDE\u2010injected mice showed reduced body weights, increased insulin sensitivity, decreased hepatic lipid deposition, reduced senescence, and augmented autophagy levels compared with the aged group of mice. The in\u00a0vitro results were consistent with the in\u00a0vivo results. When autophagy\u2010related genes were silenced in AML12 cells via small interfering RNAs, or when cells were treated with the autophagy inhibitor 3\u2010methyladenine or the lysosomal inhibitor bafilomycin A1, HucMDEs were able to reverse the reduction in hepatocyte autophagy levels. In this study, we demonstrated that HucMDEs improved hepatic lipid metabolism and attenuated cellular senescence by enhancing autophagy. We expect that these findings will provide novel potential therapeutic targets for the treatment of hepatic lipid metabolism disorders during aging.<\/jats:p>","DOI":"10.1111\/acel.70642","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:42:52Z","timestamp":1784259772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal Stem Cell\u2010Derived Exosomes Improve Aging\u2010Related Changes in Liver Lipid Metabolism by Enhancing Autophagy"],"prefix":"10.1111","volume":"25","author":[{"given":"Jinquan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinke","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dini","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases  Jinan China"},{"name":"Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chronic Metabolic Diseases  Jinan China"},{"name":"Institute of Endocrine and Metabolic Diseases of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-8367","authenticated-orcid":false,"given":"Ming","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Qilu Hospital of Shandong University  Jinan China"},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases  Jinan China"},{"name":"Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chronic Metabolic Diseases  Jinan China"},{"name":"Institute of Endocrine and Metabolic Diseases of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.026"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010022\u201000620\u2010x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102849"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202400598"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710055"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006248\u20109"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020652"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201028436\u2010z"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.044"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101635"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010020\u201010121\u20102"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.162"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010012615\u2010044224"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201083112\u20100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.04.003"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009598\u20109"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20100791\u20107"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010021\u201000551\u20109"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111114"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010025\u201004318\u20101"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1181308"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201015495\u20107"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316880"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106751"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12708"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.63"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060824"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30834"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1834711"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100973"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202000383"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.07.008"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15\u20100291"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13532"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010021\u201002138\u20107"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27140"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13238"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27420"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103606"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113331"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155200"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.113"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010022\u201000383\u20102"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158267"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201040543\u20105"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00032.2011"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020183"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70642","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:57:58Z","timestamp":1784609878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/acel.70642"],"URL":"https:\/\/doi.org\/10.1111\/acel.70642","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70642"}}