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In this study, we aimed to investigate the involvement of intestinal fungi in the exacerbation of arterial stiffness. In total, 763 participants were invited for the brachial\u2010ankle pulse wave velocity test to determine their status of arterial stiffness. The gut mycobiome was identified through internal transcribed spacer sequencing, host genetics were determined by genotyping arrays, and plasma metabolites were quantified using untargeted liquid chromatography\u2010mass spectrometry. A less clustered but more communicative fungal community was found in individuals with elevated stiffness. Five driving fungal genera contributing to the shift of fungal interaction networks from normal to elevated stiffness, including\n                    <jats:italic>Apiotrichum<\/jats:italic>\n                    ,\n                    <jats:italic>Mycothermus<\/jats:italic>\n                    ,\n                    <jats:italic>Flavocillium<\/jats:italic>\n                    ,\n                    <jats:italic>Hyaloscypha<\/jats:italic>\n                    , and\n                    <jats:italic>Microscypha<\/jats:italic>\n                    , were associated with arterial stiffness. Integrative analysis with metabolomics further demonstrated that organic acids, fatty acyls, and alkaloids mediated the effect of\n                    <jats:italic>Apiotrichum<\/jats:italic>\n                    ,\n                    <jats:italic>Mycothermus<\/jats:italic>\n                    , and\n                    <jats:italic>Microscypha<\/jats:italic>\n                    on arterial stiffness. Moreover, alpha\u20101A adrenergic receptor, alpha\u20102B adrenergic receptor, cytochrome P450 Family 11 subfamily B member 2, angiotensin I converting enzyme, angiotensin II receptor type 1, matrix metallopeptidase 2, tumor necrosis factor, and rho\u2010associated coiled\u2010coil containing protein kinase 2 were identified as the key molecular transducers associated with increased\n                    <jats:italic>Apiotrichum<\/jats:italic>\n                    in arterial stiffness. Our study uncovers a strong association between disruption in gut fungi and the progression of elevated arterial stiffness, and highlights the potential of targeting the gut mycobiome for improving vascular health.\n                  <\/jats:p>","DOI":"10.1111\/acel.70650","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:54:07Z","timestamp":1785048847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Apiotrichum<\/i>\n                    \u2010Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-8434","authenticated-orcid":false,"given":"Jiarui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health Sun Yat\u2010sen University  Guangzhou People's Republic of 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Y.Cang Y.Li et\u00a0al.2023.\u201cNon\u2010Invasive Monitoring and Classification of Coronary Heart Disease by Metabolomics and Lipidomics.\u201d","DOI":"10.21203\/rs.3.rs-3577837\/v1"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01024-x"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-022-00247-8"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-021-01157-2"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1480-9"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022367"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000151373.33830.41"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx034"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-017-0912-5"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100625"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124844"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:10:58Z","timestamp":1787321458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/acel.70650"],"URL":"https:\/\/doi.org\/10.1111\/acel.70650","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70650"}}