{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:31Z","timestamp":1790574931877,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82394424"],"award-info":[{"award-number":["82394424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20404"],"award-info":[{"award-number":["U23A20404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03199"],"award-info":[{"award-number":["2024C03199"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase. As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders; however, its role in regulating age\u2010related decidualization disorders remains unreported. In this study, we identified pronounced decidualization defects in AMA foster mice, accompanied by a significant reduction in RICTOR in the decidual tissues of AMA women. Uterine\u2010specific genetic deletion of\n                    <jats:italic>Rictor<\/jats:italic>\n                    in mice resulted in pregnancy loss and impaired decidualization. Notably,\n                    <jats:italic>Rictor<\/jats:italic>\n                    knockdown led to attenuated Akt3\u2013FoxO1 signaling and impaired nuclear export of FoxO1. Molecular and histological analyses demonstrated that the specific RICTOR activator MHY1485 effectively rescued decidualization defects in\u00a0vivo and in\u00a0vitro. These findings indicate that RICTOR plays an essential role in the aging decidual microenvironment and may serve as a potential biomarker for uterine stromal cell decidualization. Furthermore, therapeutic activation of RICTOR represents a promising strategy to counteract senescent decidual impairment in AMA women and improve pregnancy outcomes.\n                  <\/jats:p>","DOI":"10.1111\/acel.70667","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:50:26Z","timestamp":1787302226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>RICTOR<\/scp>\n                    Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating\n                    <scp>FoxO1<\/scp>\n                    Nuclear Export"],"prefix":"10.1111","volume":"25","author":[{"given":"Yifeng","family":"Lin","sequence":"first","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"},{"name":"Center for Reproductive Medicine, the First Affiliated Hospital, School of Medicine Zhejiang University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-3115","authenticated-orcid":false,"given":"Yue","family":"Ying","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Ying","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-0006","authenticated-orcid":false,"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-4795","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Institute of Medical Genetics and Development, Zhejiang University  Zhejiang China"},{"name":"Zhejiang Provincial Birth Defect Control and Prevention Research Center  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Genetics 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