{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:47:02Z","timestamp":1787323622843,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001479"],"award-info":[{"award-number":["82001479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101351"],"award-info":[{"award-number":["82101351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ischemic postconditioning (I\/Post), which is an effective intervention by activating endogenous cardioprotective pathways, recovers ischemia\/reperfusion injury. However, this intervention is not as effective in older patients, and its mechanism needs to be further investigated. In this study, we found that myocardial telomeric repeat binding factor 2 (TRF2) protein expression in male aged mice (18\u2009months of age) was lower than that in male adult mice (4\u2009months of age). After ligation of the anterior descending branch of the heart to establish an in\u00a0vivo model of ischemia\/reperfusion injury, we found that TRF2 expression was further decreased after I\/Post. To investigate the role of TRF2 in cardioprotection in I\/Post in the senescent heart, we performed echocardiography, blood biochemical testing, and apoptosis\u2010related detection after injecting adeno\u2010associated virus type 9 overexpressing TRF2 into aged mice. We found that TRF2 improved myocardial I\/Post protection in\u00a0vivo. Knockdown of TRF2 in a cardiomyocyte cell line (HL\u20101) increased inflammatory factor release and aggravated mitochondrial and DNA damage in senescent myocardiocytes following hypoxic postconditioning (H\/Post). TRF2 also inhibited activation of the cGAS\/STING pathway by increasing mitophagy during H\/Post in aged myocardiocytes. Moreover, TRF2 interacted with casein kinase 2 alpha 2 polypeptide (CSNK2A2) to regulate the dephosphorylation of FUN14 domain\u2010containing protein 1 (FUNDC1), which contributed to the protective effect of hypoxic postconditioning.<\/jats:p>","DOI":"10.1111\/acel.70669","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:17:03Z","timestamp":1786958223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TRF2<\/scp>\n                    Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating\n                    <scp>CSNK2A2<\/scp>\n                    Localization and\n                    <scp>FUNDC1<\/scp>\n                    Dephosphorylation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0494-7691","authenticated-orcid":false,"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin Union Medical Center Nankai University Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Shu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7969-8025","authenticated-orcid":false,"given":"Yiqing","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin 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