{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:47:01Z","timestamp":1787323621284,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20398"],"award-info":[{"award-number":["U23A20398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vascular aging, not only a victim of vascular cell senescence but also a driving hub of systemic aging, is a complex process in which both anti\u2010aging and pro\u2010aging proteins are involved. Thus, the ideal anti\u2010aging medication should have multiple protein targets; in this case, an lncRNA might be a good choice. AK050834 is a conserved lncRNA, but its roles in vascular biology and vascular aging are currently unknown. Here, we identified that AK050834 was highly expressed in vascular walls and in vascular smooth muscle cells (VSMCs). Notably, AK050834 expression was remarkably increased in aged vessels. By using gain\u2010of\u2010function, loss\u2010of\u2010function, and gene knockout approaches, we identified that AK050834 is a strong regulator of VSMC senescence and vascular aging. In terms of the mechanisms, we found that AK050834 suppressed the expression of the anti\u2010aging protein ATF3 via direct interaction with its promoter, which was further confirmed by a rescue experiment. In addition, AK050834 increased the expression of the pro\u2010aging protein p21 by stabilizing its mRNA. Finally, we found that AK050834 deficiency could effectively prevent vascular aging in mice in\u00a0vivo. The interesting dual and opposite effects of AK050834 on the anti\u2010aging protein ATF3 and the pro\u2010aging protein p21 suggest that AK050834 might be a novel diagnostic marker as well as an ideal therapeutic and preventive target for vascular aging and many related diseases.<\/jats:p>","DOI":"10.1111\/acel.70670","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:04:14Z","timestamp":1787054654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AK050834 Deficiency Prevents Vascular Aging via Opposite Regulation of Two Senescence\u2010Sensitive Genes ATF3 and p21"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7646-0572","authenticated-orcid":false,"given":"Haoran","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1641-9690","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Affiliated Hospital, Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Affiliated Hospital, Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104959"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102824"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311727"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202518056"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-021-00271-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12933"},{"issue":"6","key":"e_1_2_10_9_1","article-title":"Intracellular Calcium Overload Promotes NFATc1\u2010ATF3 Activation and Induces the Senescence\u2010Associated Phenotype in Irradiated Osteocytes","volume":"16","author":"Han 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