{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:47:23Z","timestamp":1787953643142,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS124735"],"award-info":[{"award-number":["1R01NS124735"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009356","name":"Thomas Hartman Foundation for Parkinson\u2019s Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>One of the defining phenotypes of a senescent cell is the senescence\u2010associated secretory phenotype (SASP), which can propagate senescence in neighboring cells both in\u00a0vitro and in\u00a0vivo. Importantly, this paracrine spreading of senescence can act in a cell non\u2010autonomous manner, influencing neighboring cell populations and contributing to immune cell recruitment. As cellular senescence has recently been linked to both age\u2010related neurodegenerative phenotypes and local inflammation and is more clearly defined across brain cell types in a cell\u2010type\u2010dependent manner, an urgent question remains regarding how a cell\u2010type\u2010specific paracrine spreading of senescence occurs in the brain. Here, we set out to profile the cell\u2010type\u2010specific features of the SASP and characterize the directionality of paracrine senescence\u2010spreading between major brain cell types. Through this analysis, we identified key SASP ligand\u2010receptor pairs involved in this paracrine dissemination. Targeting selected factors with specific inhibitors, we ameliorated some aspects of the paracrine spreading of senescence in a brain cell\u2010type\u2010dependent manner. Taken together, we identified specific SASP targets for therapeutic intervention in the context of human brain cells and thereby informed the SASP\u2010dependent reaction of immune cells and age\u2010related tissue dysfunction across both normal aging and models of neurodegenerative disease.<\/jats:p>","DOI":"10.1111\/acel.70673","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:10:33Z","timestamp":1786777833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing the\n                    <scp>SASP<\/scp>\n                    \u2010Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-5366","authenticated-orcid":false,"given":"Taylor","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior Stony Brook University  Stony Brook New York USA"},{"name":"Center for Nervous System Disorders Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2592-5045","authenticated-orcid":false,"given":"Markus","family":"Riessland","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior Stony Brook University  Stony Brook New York USA"},{"name":"Center for Nervous System Disorders Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1733"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2784"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101412"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2026.03.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16932"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162588"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092233"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0286-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.092"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101569"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060301"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12848"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00040"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-171"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(61)90192-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI165933"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.07.033"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2024.09.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.302570.117"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-202106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.06.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.23.3510"},{"key":"e_1_2_10_27_1","article-title":"The 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