{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:25Z","timestamp":1790574925348,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/X000567\/1"],"award-info":[{"award-number":["BB\/X000567\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Z514743\/1"],"award-info":[{"award-number":["BB\/Z514743\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["300350\/Z\/23\/Z"],"award-info":[{"award-number":["300350\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020172","name":"Royal National Institute for Deaf People","doi-asserted-by":"publisher","award":["G106"],"award-info":[{"award-number":["G106"]}],"id":[{"id":"10.13039\/501100020172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mammalian cochlear hair cells convert acoustic stimuli into electrical signals, which are relayed to the central auditory pathway via auditory neurons. Progressive loss of hair cells and their synapses is a characteristic of age\u2010related hearing loss (ARHL), but the underlying mechanisms remain poorly understood. In this study, we tested the hypothesis that hair cell physiological properties change with age in CBA\/CaJ mice, a strain known for its slow ARHL progression. We found that hair cell size began to decrease from 10\u2009months of age, well before detectable increase in hearing thresholds from auditory brainstem responses. This structural change was associated with a significant decrease in the size of the basolateral membrane current, in particular that carried by the large conductance calcium\u2010activated potassium (BK) channel currents (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>K,f<\/jats:sub>\n                    ) in the apical inner hair cells (IHCs). However, the size of the mechanoelectrical transducer (MET) current measured in the IHCs remained unaffected at least up to 22\u2009months of age. Our results provide clear evidence of an early change in the physiological properties of apical IHCs with age, which precedes measurable hearing loss, suggesting that these cellular deficits might define a distinct pathological route in the CBA\/CaJ mice.\n                  <\/jats:p>","DOI":"10.1111\/acel.70679","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:21:59Z","timestamp":1787296919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging Alters Hair Cell Physiological Properties in Mice With Late\u2010Onset Age\u2010Related Hearing Loss"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-4510","authenticated-orcid":false,"given":"Piece","family":"Yen","sequence":"first","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-3901","authenticated-orcid":false,"given":"Adam J.","family":"Carlton","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0693-6251","authenticated-orcid":false,"given":"Andrew","family":"O'Connor","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niovi","family":"Voulgari","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-650X","authenticated-orcid":false,"given":"Stuart L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-8597","authenticated-orcid":false,"given":"Jing\u2010Yi","family":"Jeng","sequence":"additional","affiliation":[{"name":"School of Biosciences University of Sheffield  Sheffield UK"},{"name":"Neuroscience Institute University of Sheffield  Sheffield 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