{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:32Z","timestamp":1790574932433,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372389"],"award-info":[{"award-number":["82372389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772354"],"award-info":[{"award-number":["2025M772354"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong Municipality","doi-asserted-by":"publisher","award":["JC2025009"],"award-info":[{"award-number":["JC2025009"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging increases tendon injury incidence and poor repair outcomes, but age\u2010related differences in tendon mechanical properties and underlying mechanisms remain unclear. We first analyzed data from the Global Burden of Disease (GBD) database to characterize the associations between aging and population\u2010level changes in tendon injury burden. We found the age\u2010standardized incidence rate (ASIR) of tendon injuries caused by mechanical force decreased with advancing age, whereas the age\u2010standardized prevalence rate (ASPR) increased with age, and the years lived with disability (YLDs) due to tendon injuries also showed an increasing trend with age. Guided by these epidemiological observations, we further performed ex\u00a0vivo biomechanical assessments using aged rat flexor digitorum longus (FDL) tendon injury models to validate age\u2010related mechanical deterioration at the tissue level, revealing significantly compromised mechanical properties in aged female rat tendons. To uncover the molecular drivers underlying such age\u2010dependent mechanical degeneration, we conducted single\u2010cell RNA sequencing of tendon tissues and identified downregulated expression of\n                    <jats:italic>Col1a1<\/jats:italic>\n                    and\n                    <jats:italic>Sparc<\/jats:italic>\n                    in aged tendons. According to the JASPAR website prediction, the transcription factor Creb3l1 could bind to the promoter regions of both\n                    <jats:italic>Col1a1<\/jats:italic>\n                    and\n                    <jats:italic>Sparc<\/jats:italic>\n                    genes simultaneously, and its overexpression promoted their expression. Finally, in\u00a0vivo Creb3l1 overexpression upregulated the levels of Col1a1 and Sparc proteins and improved the gliding function, healing strength, and elastic modulus of aged tendons, especially in aged male rats. Collectively, this study links population\u2010based epidemiological evidence with preclinical functional and mechanistic validation, providing insights for risk prediction and novel therapeutic targets for age\u2010related tendon injuries.\n                  <\/jats:p>","DOI":"10.1111\/acel.70682","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:25:15Z","timestamp":1787545515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats"],"prefix":"10.1111","volume":"25","author":[{"given":"Qian Qian","family":"Yang","sequence":"first","affiliation":[{"name":"Hand Surgery Research Center, Research Center of Clinical Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-8625","authenticated-orcid":false,"given":"Zhanghao","family":"Huang","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Affiliated Hospital of Nantong University  Nantong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xue","sequence":"additional","affiliation":[{"name":"Hand Surgery Research Center, Research Center of Clinical Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Hand Surgery Research Center, Research Center of Clinical Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-974X","authenticated-orcid":false,"given":"You Lang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hand Surgery Research Center, Research Center of Clinical Medicine Affiliated Hospital of Nantong University, Medical School of Nantong University  Nantong P.R. 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