{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:33Z","timestamp":1790574933580,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A2002"],"award-info":[{"award-number":["U25A2002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3605200"],"award-info":[{"award-number":["2023YFC3605200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic intermittent hypoxia (CIH), a cardinal pathophysiological feature of obstructive sleep apnea (OSA), repeatedly exposes the heart to hypoxia\u2010reoxygenation stress. The cardiac outcome of CIH, however, may depend on the biological state of the target myocardium. Here, we investigated whether a pre\u2010existing aging\u2010related myocardial susceptibility lowers the tolerance threshold for CIH\u2010induced injury and whether Dynamin\u2010related protein 1 (Drp1) contributes to the enhanced vulnerability of senescence\u2010like cardiomyocytes under CIH. Using G3 Tert\u2010deficient (Tert\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice and D\u2010galactose (D\u2010gal)\u2010induced senescence\u2010like primary cardiomyocytes, we show that aging\u2010related susceptibility consistently amplifies CIH\u2010induced cardiac injury. In young wild\u2010type mice, 8\u2009weeks CIH induced early cardiac remodeling and senescence\u2010associated myocardial stress without overt systolic decompensation. In Tert\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, the same CIH exposure shifted the cardiac response further toward maladaptive remodeling. Compared with CIH alone, EF and FS were reduced by an additional 24.6% and 15.8%, respectively. In senescence\u2010like cardiomyocytes, CIH amplified mitochondrial vulnerability, with impaired energy production, elevated mitochondrial oxidative stress, and a fission\u2010biased mitochondrial dynamics marker profile. Drp1 knockdown did not fully reverse this mitochondrial state but restored 55.1% of the CIH\u2009+\u2009D\u2010gal induced ATP decline and reversed 47.4% of the mitochondrial ROS excess, while attenuating DNA damage response activation and senescence\u2010associated signaling. These findings indicate that aging\u2010related myocardial susceptibility is not a passive contextual factor in CIH\u2010induced injury but a biological state that actively shapes the cardiac response to repeated hypoxia\u2010reoxygenation stress. Drp1\u2010associated mitochondrial dynamics imbalance may represent a functional link between diminished mitochondrial stress tolerance and amplified cardiomyocyte vulnerability.\n                  <\/jats:p>","DOI":"10.1111\/acel.70684","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:34:41Z","timestamp":1787715281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging\u2010Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin\u2010Related Protein 1\u2010Associated Mitochondrial Vulnerability"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5229-0164","authenticated-orcid":false,"given":"Yinghui","family":"Su","sequence":"first","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital, Key Laboratory of Post\u2010Neuroinjury Neuro\u2010Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-9687","authenticated-orcid":false,"given":"Yuyang","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital, Key Laboratory of Post\u2010Neuroinjury Neuro\u2010Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital, Key Laboratory of Post\u2010Neuroinjury Neuro\u2010Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5238-8704","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Basic Medical Science Tianjin Medical University, The Province and Ministry Co\u2010Sponsored Collaborative Innovation Center for Medical Epigenetics  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5686-9253","authenticated-orcid":false,"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital, Key Laboratory of Post\u2010Neuroinjury Neuro\u2010Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00632.2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100492"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(19)30198\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86387"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016369"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010024\u201005239\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab161"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000461"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010018\u20100133\u20100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3514"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010024\u201000170\u20104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15091088"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.07.024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.02.059"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.02.973"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103208"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3213"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302095"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.180869"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg013"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307505"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.11.009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032904"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318241"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.20517\/jca.2023.4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010021\u201000624\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158447"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0000000000000104"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010024\u201000588\u20104"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4777"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2025.112686"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301040RR"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010023\u201000113\u20105"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000846\u20106"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020502"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000785\u20101"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.325676"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17580"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70417"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000988"}],"container-title":["Aging 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