{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:29Z","timestamp":1790574929566,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME3696\/5\u20101"],"award-info":[{"award-number":["ME3696\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR\u2010298 SIIRI\u2014Project\u2010ID 426335750"],"award-info":[{"award-number":["SFB\/TRR\u2010298 SIIRI\u2014Project\u2010ID 426335750"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging kidneys exhibit accumulation of senescent cells together with sterile low\u2010grade inflammation. However, the spatial organization of senescence\u2010associated immune cell accumulation in the aging kidney remains poorly defined. We systematically analyzed kidneys from young, middle\u2010aged, and aged mice, focusing on the spatial relationship between senescent tubular cells and distinct immune cell populations. Senescent tubular cells showed significant local enrichment of immune cells, with macrophages representing the most prominent associated immune cell population. This spatial association was more closely linked to p16\n                    <jats:sup>\n                      <jats:italic>Ink4a<\/jats:italic>\n                    <\/jats:sup>\n                    burden as an indicator of biological aging than to chronological age alone, as kidneys with higher p16\n                    <jats:sup>\n                      <jats:italic>Ink4a<\/jats:italic>\n                    <\/jats:sup>\n                    levels displayed enhanced inflammatory and SASP\u2010associated transcriptional signatures. Complementary spatial transcriptomic analyses identified a cortex\u2010restricted senescence\u2010associated neighborhood enriched for inflammatory, macrophage\u2010related, and failed\u2010repair tubular transcriptional programs, supporting the presence of localized senescence\u2010associated inflammatory niches at the transcriptomic level. Both, genetic and pharmacological senolytic interventions reduced senescent\u2010cell burden and decreased immune cell accumulation in aged kidneys. However, macrophages remained preferentially localized near residual senescent tubular structures after senolysis, consistent with persistent local immune senescent cell interactions. Our findings provide quantitative spatial evidence that senescence\u2010associated inflammatory niches emerge in the aging kidney cortex and can be modulated by senolytic intervention. Together, these results establish a spatial framework for renal inflammaging and highlight senescence\u2010associated inflammatory microenvironments as potential therapeutic targets in kidney aging.\n                  <\/jats:p>","DOI":"10.1111\/acel.70698","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:20:06Z","timestamp":1788438006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights Into the Interplay Between the Senescent Cells and Immune Cells"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5740-5023","authenticated-orcid":false,"given":"Martin","family":"Jaros","sequence":"first","affiliation":[{"name":"Department of Pediatric Kidney, Liver, Metabolic Diseases and Neuropediatrics Hannover Medical School  Germany"},{"name":"Hannover Biomedical Research School Hannover Medical School  Hannover Germany"},{"name":"Interdisciplinary Transplantation, Children's Hospital Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-3249","authenticated-orcid":false,"given":"Marco","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver, Metabolic Diseases and Neuropediatrics Hannover Medical School  Germany"},{"name":"Interdisciplinary Transplantation, Children's Hospital Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-4185","authenticated-orcid":false,"given":"Lavinia","family":"Neubert","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Hannover Medical School  Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover German Center for Lung Research  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-409X","authenticated-orcid":false,"given":"Jan\u2010Christopher","family":"Kamp","sequence":"additional","affiliation":[{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover German Center for Lung Research  Hannover Germany"},{"name":"Department of Respiratory Medicine Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3217-5433","authenticated-orcid":false,"given":"Sibylle","family":"von Vietinghoff","sequence":"additional","affiliation":[{"name":"Nephrology Section, Medical Clinic 1 University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-3067","authenticated-orcid":false,"given":"Jan Hinrich","family":"Br\u00e4sen","sequence":"additional","affiliation":[{"name":"Nephropathology Unit, Institute for Pathology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-8355","authenticated-orcid":false,"given":"Roland","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hannover Medical School  Hannover Germany"},{"name":"Klinik f\u00fcr Innere Medizin IV mit den Schwerpunkten Nieren\u2010 Und Hochdruckkrankheiten University Medical Center Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-6318","authenticated-orcid":false,"given":"Anette","family":"Melk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver, Metabolic Diseases and Neuropediatrics Hannover Medical School  Germany"},{"name":"Interdisciplinary Transplantation, Children's Hospital Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.689799"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017204\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/Asn.2011100967"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010025\u201002161\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20102277.2011.01272.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010121808\u2010102144"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08296"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162519"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026684118"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100991"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/Asn.2017040421"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005477117"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35092584"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084168"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010020\u201003719\u20100"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016158\u2010z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/Asn.2020081143"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2005.00846.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2004.00438.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb0203"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000395"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.11.015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051186\u2010z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/Cs20230140"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032552\u20101"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00543.2007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.02.036"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1222339"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.10.009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201089442\u20107"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102818.2010.03445.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000107\u20106"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.359"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.099432"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062599\u20109"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad063c_6727"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13858"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.805420"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12344"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:07:23Z","timestamp":1790572043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/acel.70698"],"URL":"https:\/\/doi.org\/10.1111\/acel.70698","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70698"}}